Index by author
July 01, 2022; Volume 50,Issue 7
A
Abdullahi, Wazir
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Amory, John K.
- You have accessIsotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the ClinicAprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina IsoherranenDrug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
Arbanas, Jaren
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
B
Berger, Allison
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
Betterton, Robert D.
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Bois, Frederic Y.
- Open AccessUnderstanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic FrameworkMian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud JameiDrug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
Bolleddula, Jayaprakasam
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
Broz, Miranda
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Brzica, Hrvoje
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
C
Carl, Stephen
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Chan, Eric Chun Yong
- You have accessMetabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3ALloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong ChanDrug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
Chen, Hao
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
Cheng, Yuan
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Chothe, Paresh P.
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Chowdhury, Swapan K
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Chowdhury, Swapan K.
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
Chu, Xiaoyan
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
Chuang, Bei-Ching
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Cohen, Lawrence
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
Collier, Hannah
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
D
Davis, Thomas P.
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
F
Fisher, Ciarán
- Open AccessUnderstanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic FrameworkMian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud JameiDrug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
Fotinich, Anna
- You have accessThe Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In VitroNatalia Mast, Anna Fotinich and Irina A. PikulevaDrug Metabolism and Disposition July 2022, 50 (7) 923-930; DOI: https://doi.org/10.1124/dmd.122.000874
Fu, Jiaxin
- You have accessMetabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3ALloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong ChanDrug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
G
Gardner, Iain
- Open AccessUnderstanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic FrameworkMian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud JameiDrug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
Graziano, Robert F.
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Gururajan, Murali
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
H
Hittle, Lucinda
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
Honkakoski, Paavo
- You have accessSearching for Constitutive Androstane Receptor ModulatorsPaavo HonkakoskiDrug Metabolism and Disposition July 2022, 50 (7) 1002-1009; DOI: https://doi.org/10.1124/dmd.121.000482
Houle, Robert
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
I
Isoherranen, Nina
- You have accessIsotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the ClinicAprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina IsoherranenDrug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
J
Jamei, Masoud
- Open AccessUnderstanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic FrameworkMian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud JameiDrug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
K
Kaminski, Andrea M.
- You have accessFrom Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor FunctionLars C. Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M. KaminskiDrug Metabolism and Disposition July 2022, 50 (7) 1027-1041; DOI: https://doi.org/10.1124/dmd.121.000478
Katwaru, Ravi
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
Kenny, Jane R.
- You have accessIsotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the ClinicAprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina IsoherranenDrug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
Kilford, Peter
- Open AccessUnderstanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic FrameworkMian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud JameiDrug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
Koh, Siew Kwan
- You have accessMetabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3ALloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong ChanDrug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
Kosaka, Mika
- You have accessIsotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the ClinicAprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina IsoherranenDrug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
Krystek, Stanley
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Kurian, Ritika
- You have accessClinical Relevance of the Constitutive Androstane ReceptorSydney Stern, Ritika Kurian and Hongbing WangDrug Metabolism and Disposition July 2022, 50 (7) 1010-1018; DOI: https://doi.org/10.1124/dmd.121.000483
L
Lai, Yurong
- You have accessSpecial Section on Drug Metabolism and Regulation—EditorialXiao-bo Zhong and Yurong LaiDrug Metabolism and Disposition July 2022, 50 (7) 998-999; DOI: https://doi.org/10.1124/dmd.122.000925
Lehman-McKeeman, Lois
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Liaw, Andy
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
Lin, Zheng
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Lochhead, Jeffrey J.
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Loy, James
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
M
Markowitz, John S.
- You have accessPrediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic ModelsYuli Qian and John S. MarkowitzDrug Metabolism and Disposition July 2022, 50 (7) 968-979; DOI: https://doi.org/10.1124/dmd.121.000823
Mast, Natalia
- You have accessThe Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In VitroNatalia Mast, Anna Fotinich and Irina A. PikulevaDrug Metabolism and Disposition July 2022, 50 (7) 923-930; DOI: https://doi.org/10.1124/dmd.122.000874
Mehl, John
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Morin, Paul
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
O
Ogbonnaya, Chidinma
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Omura, Tsuneo
- You have accessPerspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical CompoundsTsuneo OmuraDrug Metabolism and Disposition July 2022, 50 (7) 1000-1001; DOI: https://doi.org/10.1124/dmd.122.000891
P
Pace, Samantha
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Pan, Xian
- Open AccessUnderstanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic FrameworkMian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud JameiDrug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
Pedersen, Lars C.
- You have accessFrom Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor FunctionLars C. Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M. KaminskiDrug Metabolism and Disposition July 2022, 50 (7) 1027-1041; DOI: https://doi.org/10.1124/dmd.121.000478
Pedersen, Lee G.
- You have accessFrom Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor FunctionLars C. Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M. KaminskiDrug Metabolism and Disposition July 2022, 50 (7) 1027-1041; DOI: https://doi.org/10.1124/dmd.121.000478
Pikuleva, Irina A.
- You have accessThe Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In VitroNatalia Mast, Anna Fotinich and Irina A. PikulevaDrug Metabolism and Disposition July 2022, 50 (7) 923-930; DOI: https://doi.org/10.1124/dmd.122.000874
Poirson, Brian
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Pusalkar, Sandeepraj
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
Q
Qian, Yuli
- You have accessPrediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic ModelsYuli Qian and John S. MarkowitzDrug Metabolism and Disposition July 2022, 50 (7) 968-979; DOI: https://doi.org/10.1124/dmd.121.000823
R
Rajendran, Surendran
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Reddell, Elizabeth
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Ronaldson, Patrick T.
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
S
Sandoval, Philip
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Sedarati, Farhad
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
Shizu, Ryota
- You have accessDistinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer DevelopmentKouichi Yoshinari and Ryota ShizuDrug Metabolism and Disposition July 2022, 50 (7) 1019-1026; DOI: https://doi.org/10.1124/dmd.121.000481
Spires, Vanessa
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Stanton, Joshua
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Stern, Sydney
- You have accessClinical Relevance of the Constitutive Androstane ReceptorSydney Stern, Ritika Kurian and Hongbing WangDrug Metabolism and Disposition July 2022, 50 (7) 1010-1018; DOI: https://doi.org/10.1124/dmd.121.000483
Stevison, Faith
- You have accessIsotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the ClinicAprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina IsoherranenDrug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
T
Tang, Lloyd Wei Tat
- You have accessMetabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3ALloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong ChanDrug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
V
Vasudevan, Krishna
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Venkatakrishnan, Karthik
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
W
Wang, Hongbing
- You have accessClinical Relevance of the Constitutive Androstane ReceptorSydney Stern, Ritika Kurian and Hongbing WangDrug Metabolism and Disposition July 2022, 50 (7) 1010-1018; DOI: https://doi.org/10.1124/dmd.121.000483
Wang, Shubing
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
Wang, Yun
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Williams, Erica I.
- You have accessRegulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. RonaldsonDrug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Wong, Susan
- You have accessIsotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the ClinicAprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina IsoherranenDrug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
Wu, Guoyi
- You have accessMetabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3ALloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong ChanDrug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
X
Xu, Shihua
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Y
Yabut, Jocelyn
- You have accessSelection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition AssaysJocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan ChuDrug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
Yadav, Aprajita S.
- You have accessIsotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the ClinicAprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina IsoherranenDrug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
Yang, Zheng
- You have accessTarget-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active DosesZheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. GrazianoDrug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
Yi, MyeongJin
- You have accessFrom Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor FunctionLars C. Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M. KaminskiDrug Metabolism and Disposition July 2022, 50 (7) 1027-1041; DOI: https://doi.org/10.1124/dmd.121.000478
Yoneyama, Tomoki
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Yoshinari, Kouichi
- You have accessDistinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer DevelopmentKouichi Yoshinari and Ryota ShizuDrug Metabolism and Disposition July 2022, 50 (7) 1019-1026; DOI: https://doi.org/10.1124/dmd.121.000481
Yucha, Robert W.
- Open AccessSinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance ModelPhilip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. ChotheDrug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Z
Zhang, Mian
- Open AccessUnderstanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic FrameworkMian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud JameiDrug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
Zhong, Xiao-bo
- You have accessSpecial Section on Drug Metabolism and Regulation—EditorialXiao-bo Zhong and Yurong LaiDrug Metabolism and Disposition July 2022, 50 (7) 998-999; DOI: https://doi.org/10.1124/dmd.122.000925
Zhou, Lei
- You have accessMetabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3ALloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong ChanDrug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
Zhou, Xiaofei
- Open AccessMetabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid TumorsJayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. ChowdhuryDrug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
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