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Research ArticleArticle

Prediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models

Yuli Qian and John S. Markowitz
Drug Metabolism and Disposition July 2022, 50 (7) 968-979; DOI: https://doi.org/10.1124/dmd.121.000823

Article Information

vol. 50 no. 7 968-979
DOI 
https://doi.org/10.1124/dmd.121.000823
PubMed 
35512806
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 22, 2021
  • Accepted April 12, 2022
  • Published online July 6, 2022.

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Copyright & Usage 
U.S. Government work not protected by U.S. copyright.

Author Information

  1. Yuli Qian and
  2. John S. Markowitz
  1. Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida
  1. Address correspondence to:
    Dr. John S. Markowitz, Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, 1600 SW Archer Road, RM PG-23, Gainesville, FL 32610-0486. E-mail: jmarkowitz{at}cop.ufl.edu
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CES1 Mediated DDI between Methylphenidate and Cannabinoids

Yuli Qian and John S. Markowitz
Drug Metabolism and Disposition July 1, 2022, 50 (7) 968-979; DOI: https://doi.org/10.1124/dmd.121.000823
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