Research ArticleArticle
Open Access
Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. Chothe
Drug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Philip Sandoval
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
Bei-Ching Chuang
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
Lawrence Cohen
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
Tomoki Yoneyama
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
Sandeepraj Pusalkar
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
Robert W. Yucha
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
Swapan K Chowdhury
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
Paresh P. Chothe
Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts
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Research ArticleArticle
Uptake as the RDS in Pevonedistat Hepatic Clearance
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. Chothe
Drug Metabolism and Disposition July 1, 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Research ArticleArticle
Uptake as the RDS in Pevonedistat Hepatic Clearance
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. Chothe
Drug Metabolism and Disposition July 1, 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
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