Advertisement

Index by author

August 01, 2022; Volume 50,Issue 8

A

  1. Ahmed, Anika N.

    1. Examining Physiologically Based Pharmacokinetic Model Assumptions for Cross-Tissue Similarity of Activity per Unit of Enzyme: The Case Example of Uridine 5′-Diphosphate Glucuronosyltransferase
      Anika N. Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub
      Drug Metabolism and Disposition August 2022, 50 (8) 1119-1125; DOI: https://doi.org/10.1124/dmd.121.000813

  2. Al-Majdoub, Zubida M.

    1. Examining Physiologically Based Pharmacokinetic Model Assumptions for Cross-Tissue Similarity of Activity per Unit of Enzyme: The Case Example of Uridine 5′-Diphosphate Glucuronosyltransferase
      Anika N. Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub
      Drug Metabolism and Disposition August 2022, 50 (8) 1119-1125; DOI: https://doi.org/10.1124/dmd.121.000813

  3. Alifrangis, Lene

    1. <em>In Vitro</em> CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen
      Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865

  4. Armstrong, Laura

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

B

  1. Banfield, Christopher

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  2. Barber, Jill

    1. Examining Physiologically Based Pharmacokinetic Model Assumptions for Cross-Tissue Similarity of Activity per Unit of Enzyme: The Case Example of Uridine 5′-Diphosphate Glucuronosyltransferase
      Anika N. Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub
      Drug Metabolism and Disposition August 2022, 50 (8) 1119-1125; DOI: https://doi.org/10.1124/dmd.121.000813

  3. Bauman, Jonathan N.

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  4. Bittner, Anton

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  5. Broccatelli, Fabio

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

  6. Brown, Lauren G.

    1. HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/<em>β</em>-Catenin Signaling
      HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling
      Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett
      Drug Metabolism and Disposition August 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870

  7. Brown, Suzanne

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

C

  1. Chang, Jae H.

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

  2. Chatterjee, Sagnik

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

  3. Chen, Cliff

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

  4. Chen, Shen-Jue

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

  5. Chen, Xue-Qing

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

  6. Coe, Kevin J.

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

D

  1. Dahl, Kirsten

    1. <em>In Vitro</em> CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen
      Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865

  2. Dexter, Heather

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

  3. DiProspero, Thomas J.

    1. HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/<em>β</em>-Catenin Signaling
      HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling
      Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett
      Drug Metabolism and Disposition August 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870

  4. Doran, Angela C.

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  5. Dowty, Martin E.

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

F

  1. Fachko, Trevor D.

    1. HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/<em>β</em>-Catenin Signaling
      HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling
      Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett
      Drug Metabolism and Disposition August 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870

  2. Feinstein, Mark

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  3. Friedrichsen, Martin Haljeta

    1. <em>In Vitro</em> CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen
      Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865

G

  1. Goosen, Theunis C.

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

H

  1. Hack, Michael

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  2. Higgins, J. William

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

J

  1. Jones, Robert S.

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

  2. Joshi, Elizabeth M.

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

K

  1. Kenny, Jane R.

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

  2. King-Ahmad, Amanda

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  3. Kinong, Jennifer

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  4. Koudriakova, Tatiana

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  5. Kristensen, Kim

    1. <em>In Vitro</em> CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen
      Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865

L

  1. Leung, Christian

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

  2. Leung, Perry

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  3. Lim, Nathan M.

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  4. Lin, Jian

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  5. Lin, Tsung H.

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  6. Liu, Ning

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

  7. Lockett, Matthew R.

    1. HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/<em>β</em>-Catenin Signaling
      HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling
      Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett
      Drug Metabolism and Disposition August 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870

M

  1. Malhotra, Bimal K.

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  2. McAllister, Heather

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

N

  1. Nygård, Sune Boris

    1. <em>In Vitro</em> CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen
      Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865

R

  1. Rostami-Hodjegan, Amin

    1. Examining Physiologically Based Pharmacokinetic Model Assumptions for Cross-Tissue Similarity of Activity per Unit of Enzyme: The Case Example of Uridine 5′-Diphosphate Glucuronosyltransferase
      Anika N. Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub
      Drug Metabolism and Disposition August 2022, 50 (8) 1119-1125; DOI: https://doi.org/10.1124/dmd.121.000813

S

  1. Säll, Carolina

    1. <em>In Vitro</em> CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
      Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen
      Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865

  2. Scott, Brian P.

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  3. Sharma, Raman

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  4. Shen, Hong

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

  5. Shuster, David J.

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

  6. Skaptason, Judy

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

T

  1. Tam, Yuen

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

  2. Telliez, Jean-Baptiste

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

  3. Tripathy, Sakambari

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

V

  1. Volak, Laurie P.

    1. Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
      Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova
      Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825

W

  1. Walker, Gregory S.

    1. Open Access
      The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
      Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty
      Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829

Y

  1. Yan, Zhengyin

    1. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
      Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli
      Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

  2. Yang, Zheng

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875

Z

  1. Zhang, Yueping

    1. Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
      Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
      Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875
Back to top

In this issue

Advertisement