Research ArticleArticle
HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling
Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett
Drug Metabolism and Disposition August 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870
Thomas J. DiProspero
Department of Chemistry, Kenan and Caudill Laboratories (T.J.D., L.G.B., T.D.F., M.R.L.), and Lineberger Comprehensive Cancer Center, School of Medicine (M.R.L.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Lauren G. Brown
Department of Chemistry, Kenan and Caudill Laboratories (T.J.D., L.G.B., T.D.F., M.R.L.), and Lineberger Comprehensive Cancer Center, School of Medicine (M.R.L.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Trevor D. Fachko
Department of Chemistry, Kenan and Caudill Laboratories (T.J.D., L.G.B., T.D.F., M.R.L.), and Lineberger Comprehensive Cancer Center, School of Medicine (M.R.L.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Matthew R. Lockett
Department of Chemistry, Kenan and Caudill Laboratories (T.J.D., L.G.B., T.D.F., M.R.L.), and Lineberger Comprehensive Cancer Center, School of Medicine (M.R.L.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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Impact of Physiological Microenvironments on HepaRG Cells
Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett
Drug Metabolism and Disposition August 1, 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870
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