Table of Contents

Articles

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  Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs

  Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli

  Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784
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  Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human

  Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova

  Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825
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  Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid

  Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen

  Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875
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  In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic

  Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen

  Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865
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  HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling

  Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett

  Drug Metabolism and Disposition August 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870
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  The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

  Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty

  Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829