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Drug Metabolism & Disposition

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Table of Contents

September 01, 2022; Volume 50,Issue 9

Special Section on New Era of Transporter Science: Unraveling the Functional Role of Orphan Transporters

  • You have access
    Special Section on New Era of Transporter Science: Unraveling the Functional Role of Orphan Transporters–Editorial
    Yurong Lai and Xiao-bo Zhong
    Drug Metabolism and Disposition September 2022, 50 (9) 1190-1192; DOI: https://doi.org/10.1124/dmd.122.001014
  • You have access
    Emerging Roles of the Human Solute Carrier 22 Family
    Sook Wah Yee and Kathleen M. Giacomini
    Drug Metabolism and Disposition September 2022, 50 (9) 1193-1210; DOI: https://doi.org/10.1124/dmd.121.000702
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    Transporters in Regulatory Science: Notable Contributions from Dr. Giacomini in the Past Two Decades
    Lei Zhang, Qi Liu, Shiew-Mei Huang and Robert Lionberger
    Drug Metabolism and Disposition September 2022, 50 (9) 1211-1217; DOI: https://doi.org/10.1124/dmd.121.000706
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    Clinical Applications and the Roles of Transporters in Disposition, Tumor Targeting, and Tissue Toxicity of meta-Iodobenzylguanidine
    Antonio J. López Quiñones, Letícia Salvador Vieira and Joanne Wang
    Drug Metabolism and Disposition September 2022, 50 (9) 1218-1227; DOI: https://doi.org/10.1124/dmd.121.000707
  • Open Access
    Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity
    Linlin Sheng, Qi Luo and Ligong Chen
    Drug Metabolism and Disposition September 2022, 50 (9) 1228-1237; DOI: https://doi.org/10.1124/dmd.121.000705
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    Transcriptional Regulation of Solute Carrier Drug Transporters
    Shiwei Zhou and Yan Shu
    Drug Metabolism and Disposition September 2022, 50 (9) 1238-1250; DOI: https://doi.org/10.1124/dmd.121.000704
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    Impact of Inflammation and Infection on the Expression of Amino Acid Transporters in the Placenta: A Minireview
    Eliza R. McColl, Milena Hurtarte and Micheline Piquette-Miller
    Drug Metabolism and Disposition September 2022, 50 (9) 1251-1258; DOI: https://doi.org/10.1124/dmd.121.000703

Articles

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    The rs35217482 (T755I) Single-Nucleotide Polymorphism in Aldehyde Oxidase-1 Attenuates Protein Dimer Formation and Reduces the Rates of Phthalazine Metabolism
    Hinata Ueda, Katsuya Narumi, Ayako Furugen, Yoshitaka Saito and Masaki Kobayashi
    Drug Metabolism and Disposition September 2022, 50 (9) 1126-1131; DOI: https://doi.org/10.1124/dmd.122.000902
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    Is the Protein-Mediated Uptake of Drugs by Organic Anion Transporting Polypeptides a Real Phenomenon or an Artifact?
    Mengyue Yin, Flavia Storelli and Jashvant D. Unadkat
    Drug Metabolism and Disposition September 2022, 50 (9) 1132-1141; DOI: https://doi.org/10.1124/dmd.122.000849
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    Antibiotics-Induced Disruption of Gut Microbiota Increases Systemic Exposure of Clopidogrel Active Metabolite in Type 2 Diabetic Rats
    Xue Chen, Yingrui Liu, Hongwei Yao, Wenfang Song, Yu Song, Jingkai Gu and Yingjie Guo
    Drug Metabolism and Disposition September 2022, 50 (9) 1142-1150; DOI: https://doi.org/10.1124/dmd.122.000906
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    The COVID-19 Oral Drug Molnupiravir Is a CES2 Substrate: Potential Drug-Drug Interactions and Impact of CES2 Genetic Polymorphism In Vitro
    Yue Shen, William Eades, William Liu and Bingfang Yan
    Drug Metabolism and Disposition September 2022, 50 (9) 1151-1160; DOI: https://doi.org/10.1124/dmd.122.000918
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    Physiologically Based Pharmacokinetic Modeling of Vitamin D3 and Metabolites in Vitamin D–Insufficient Patients
    Colton W. Sawyer, Stacey M. Tuey, Raymond E. West, Thomas D. Nolin and Melanie S. Joy
    Drug Metabolism and Disposition September 2022, 50 (9) 1161-1169; DOI: https://doi.org/10.1124/dmd.121.000609
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    Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib
    Louis Lin, Matthew R. Wright, Cornelis E.C.A. Hop and Harvey Wong
    Drug Metabolism and Disposition September 2022, 50 (9) 1170-1181; DOI: https://doi.org/10.1124/dmd.122.000885
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    High-Throughput Production of Diverse Xenobiotic Metabolites with Cytochrome P450–Transduced Huh7 Hepatoma Cell Lines
    Choon-myung Lee, Ken H. Liu, Grant Singer, Gary W. Miller, Shuzhao Li, Dean P. Jones and Edward T. Morgan
    Drug Metabolism and Disposition September 2022, 50 (9) 1182-1189; DOI: https://doi.org/10.1124/dmd.122.000900
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    Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach
    Angela C. Doran, Woodrow Burchett, Connor Landers, Gabrielle M. Gualtieri, Amanda Balesano, Heather Eng, Alyssa L Dantonio, Theunis C. Goosen and R. Scott Obach
    Drug Metabolism and Disposition September 2022, 50 (9) 1259-1271; DOI: https://doi.org/10.1124/dmd.122.000884
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    An Improved Method for Cytochrome P450 Reaction Phenotyping Using a Sequential Qualitative-Then-Quantitative Approach
    Angela C. Doran, Alyssa L. Dantonio, Gabrielle M. Gualtieri, Amanda Balesano, Connor Landers, Woodrow Burchett, Theunis C. Goosen and R. Scott Obach
    Drug Metabolism and Disposition September 2022, 50 (9) 1272-1286; DOI: https://doi.org/10.1124/dmd.122.000883
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    Pharmacokinetic Modeling of Warfarin І – Model-Based Analysis of Warfarin Enantiomers with a Target Mediated Drug Disposition Model Reveals CYP2C9 Genotype-Dependent Drug-Drug Interactions of S-Warfarin
    Shen Cheng, Darcy R. Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy
    Drug Metabolism and Disposition September 2022, 50 (9) 1287-1301; DOI: https://doi.org/10.1124/dmd.122.000876
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    Pharmacokinetic Modeling of Warfarin ІI – Model-Based Analysis of Warfarin Metabolites after Warfarin Administered Either Alone or Together with Fluconazole or Rifampin
    Shen Cheng, Darcy R. Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy
    Drug Metabolism and Disposition September 2022, 50 (9) 1302-1311; DOI: https://doi.org/10.1124/dmd.122.000877
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    Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease
    Yan Weng, Kari R. Fonseca, Yi-an Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Andrew J. Bessire, Mathew A. Cerny, David A. Tess, A. David Rodrigues, Amit S. Kalgutkar, John Litchfield, Li Di and Manthena V. S. Varma
    Drug Metabolism and Disposition September 2022, 50 (9) 1312-1321; DOI: https://doi.org/10.1124/dmd.122.000953
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Drug Metabolism and Disposition: 50 (9)
Drug Metabolism and Disposition
Vol. 50, Issue 9
1 Sep 2022
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  • Special Section on New Era of Transporter Science: Unraveling the Functional Role of Orphan Transporters
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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