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Research ArticleArticle

Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib

Louis Lin, Matthew R. Wright, Cornelis E.C.A. Hop and Harvey Wong
Drug Metabolism and Disposition September 2022, 50 (9) 1170-1181; DOI: https://doi.org/10.1124/dmd.122.000885
Louis Lin
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (L.L., H.W.) and Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (M.R.W., C.E.C.A.H.)
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Matthew R. Wright
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (L.L., H.W.) and Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (M.R.W., C.E.C.A.H.)
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Cornelis E.C.A. Hop
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (L.L., H.W.) and Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (M.R.W., C.E.C.A.H.)
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Harvey Wong
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (L.L., H.W.) and Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (M.R.W., C.E.C.A.H.)
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Article Information

vol. 50 no. 9 1170-1181
DOI 
https://doi.org/10.1124/dmd.122.000885
PubMed 
35779865

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 2, 2022
  • Accepted June 23, 2022
  • Published online August 30, 2022.

Article Versions

  • Earlier version (July 2, 2022 - 01:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Louis Lin,
  2. Matthew R. Wright,
  3. Cornelis E.C.A. Hop, and
  4. Harvey Wong
  1. Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (L.L., H.W.) and Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (M.R.W., C.E.C.A.H.)
  1. Address correspondence to:
    Dr. Harvey Wong, Faculty of Pharmaceutical Sciences, The University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. E-mail: harvey.wong{at}ubc.ca
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Aug 20222711045
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Drug Metabolism and Disposition: 50 (9)
Drug Metabolism and Disposition
Vol. 50, Issue 9
1 Sep 2022
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Research ArticleArticle

Oral PBPK Modeling of Vismodegib

Louis Lin, Matthew R. Wright, Cornelis E.C.A. Hop and Harvey Wong
Drug Metabolism and Disposition September 1, 2022, 50 (9) 1170-1181; DOI: https://doi.org/10.1124/dmd.122.000885

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Research ArticleArticle

Oral PBPK Modeling of Vismodegib

Louis Lin, Matthew R. Wright, Cornelis E.C.A. Hop and Harvey Wong
Drug Metabolism and Disposition September 1, 2022, 50 (9) 1170-1181; DOI: https://doi.org/10.1124/dmd.122.000885
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