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Drug Metabolism & Disposition

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Table of Contents

January 01, 2023; Volume 51,Issue 1

50th Anniversary Celebration Collection

  • You have access
    Celebrating 50 Years of Excellence in DMD Science
    Xinxin Ding
    Drug Metabolism and Disposition January 2023, 51 (1) 96-98; DOI: https://doi.org/10.1124/dmd.122.001179
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    Drug Metabolism: A Half-Century Plus of Progress, Continued Needs, and New Opportunities
    F. Peter Guengerich
    Drug Metabolism and Disposition January 2023, 51 (1) 99-104; DOI: https://doi.org/10.1124/dmd.121.000739
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    The Evolution of Drug Metabolism and Disposition: A Perspective From the Editors
    Edward T. Morgan, Raymond F. Novak, James R. Halpert, Eric F. Johnson and Jeffrey C. Stevens
    Drug Metabolism and Disposition January 2023, 51 (1) 105-110; DOI: https://doi.org/10.1124/dmd.122.000986
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    Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond
    Arthur G. Roberts, Jeffrey C. Stevens, Grazyna D. Szklarz, Emily E. Scott, Santosh Kumar, Manish B. Shah and James R. Halpert
    Drug Metabolism and Disposition January 2023, 51 (1) 111-122; DOI: https://doi.org/10.1124/dmd.122.001109
  • Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes
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    Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes
    Hiroshi Yamazaki and Makiko Shimizu
    Drug Metabolism and Disposition January 2023, 51 (1) 123-129; DOI: https://doi.org/10.1124/dmd.121.000742
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    COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics
    Eliza R. McColl, Maria A. Croyle, William C. Zamboni, William G. Honer, Mark Heise, Micheline Piquette-Miller and Kerry B. Goralski
    Drug Metabolism and Disposition January 2023, 51 (1) 130-141; DOI: https://doi.org/10.1124/dmd.122.000934

Articles

  • Open Access
    Cytochrome P450 Transcriptional Regulation by Testis‐Specific Y‐Encoded‐Like Protein: Identification of Novel Upstream Transcription Factors
    Suganti Shivaram, Huanyao Gao, Sisi Qin, Duan Liu, Richard M. Weinshilboum and Liewei Wang
    Drug Metabolism and Disposition January 2023, 51 (1) 1-7; DOI: https://doi.org/10.1124/dmd.122.000945
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    Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum Albumin
    Yali Wu, Lili Chen, Jian Chen, Hao Xue, Qingfeng He, Dafang Zhong and Xingxing Diao
    Drug Metabolism and Disposition January 2023, 51 (1) 8-16; DOI: https://doi.org/10.1124/dmd.122.001019
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    Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver
    Hiroyuki Ichida, Tatsuki Fukami, Keito Amai, Kohei Suzuki, Kenji Mishiro, Shiori Takano, Wataru Obuchi, Zhengyu Zhang, Akiko Watanabe, Masataka Nakano, Kengo Watanabe and Miki Nakajima
    Drug Metabolism and Disposition January 2023, 51 (1) 17-28; DOI: https://doi.org/10.1124/dmd.122.001037
  • Open Access
    CYP2C19 Plays a Major Role in the Hepatic N-Oxidation of Cotinine
    Yadira X. Perez-Paramo, Christy J.W. Watson, Gang Chen and Philip Lazarus
    Drug Metabolism and Disposition January 2023, 51 (1) 29-37; DOI: https://doi.org/10.1124/dmd.121.000624
  • A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine
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    A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine
    Yasuhiro Uno, Shiori Jikuya, Yutaro Noda, Norie Murayama and Hiroshi Yamazaki
    Drug Metabolism and Disposition January 2023, 51 (1) 38-45; DOI: https://doi.org/10.1124/dmd.121.000749
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    Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome Mapping Technology
    Xinxin Ding, John Han, Laura S. Van Winkle and Qing-Yu Zhang
    Drug Metabolism and Disposition January 2023, 51 (1) 46-53; DOI: https://doi.org/10.1124/dmd.122.001090
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    Stereoselective Metabolism of Bupropion to Active Metabolites in Cellular Fractions of Human Liver and Intestine
    Nadia O Bamfo, Jessica BL Lu and Zeruesenay Desta
    Drug Metabolism and Disposition January 2023, 51 (1) 54-66; DOI: https://doi.org/10.1124/dmd.122.000867
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    Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver
    Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari
    Drug Metabolism and Disposition January 2023, 51 (1) 67-80; DOI: https://doi.org/10.1124/dmd.122.001000
  • Sexual Dimorphism in the Expression of Cytochrome P450 Enzymes in Rat Heart, Liver, Kidney, Lung, Brain, and Small Intestine
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    Sexual Dimorphism in the Expression of Cytochrome P450 Enzymes in Rat Heart, Liver, Kidney, Lung, Brain, and Small Intestine
    Samar H. Gerges and Ayman O.S. El-Kadi
    Drug Metabolism and Disposition January 2023, 51 (1) 81-94; DOI: https://doi.org/10.1124/dmd.122.000915
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    Gut Microbiome–Wide Search for Bacterial Azoreductases Reveals Potentially Uncharacterized Azoreductases Encoded in the Human Gut Microbiome
    Domenick J. Braccia, Glory Minabou Ndjite, Ashley Weiss, Sophia Levy, Stephenie Abeysinghe, Xiaofang Jiang, Mihai Pop and Brantley Hall
    Drug Metabolism and Disposition January 2023, 51 (1) 142-153; DOI: https://doi.org/10.1124/dmd.122.000898

Erratum

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    Correction to “Identification of 5-Hydroxycotinine in the Plasma of Nicotine-Treated Mice: Implications for Cotinine Metabolism and Disposition in Vivo”
    Drug Metabolism and Disposition January 2023, 51 (1) 95; DOI: https://doi.org/10.1124/dmd.122.001059err
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    Correction to “Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver”
    Drug Metabolism and Disposition January 2023, 51 (1) 154; DOI: https://doi.org/10.1124/dmd.122.001041err
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Drug Metabolism and Disposition: 51 (1)
Drug Metabolism and Disposition
Vol. 51, Issue 1
1 Jan 2023
  • Table of Contents
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  • 50th Anniversary Celebration Collection
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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