Table of Contents

Articles

• Open Access

  Cytochrome P450 Transcriptional Regulation by Testis‐Specific Y‐Encoded‐Like Protein: Identification of Novel Upstream Transcription Factors

  Suganti Shivaram, Huanyao Gao, Sisi Qin, Duan Liu, Richard M. Weinshilboum and Liewei Wang

  Drug Metabolism and Disposition January 2023, 51 (1) 1-7; DOI: https://doi.org/10.1124/dmd.122.000945
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  Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum Albumin

  Yali Wu, Lili Chen, Jian Chen, Hao Xue, Qingfeng He, Dafang Zhong and Xingxing Diao

  Drug Metabolism and Disposition January 2023, 51 (1) 8-16; DOI: https://doi.org/10.1124/dmd.122.001019
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  Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver

  Hiroyuki Ichida, Tatsuki Fukami, Keito Amai, Kohei Suzuki, Kenji Mishiro, Shiori Takano, Wataru Obuchi, Zhengyu Zhang, Akiko Watanabe, Masataka Nakano, Kengo Watanabe and Miki Nakajima

  Drug Metabolism and Disposition January 2023, 51 (1) 17-28; DOI: https://doi.org/10.1124/dmd.122.001037
• Open Access

  CYP2C19 Plays a Major Role in the Hepatic N-Oxidation of Cotinine

  Yadira X. Perez-Paramo, Christy J.W. Watson, Gang Chen and Philip Lazarus

  Drug Metabolism and Disposition January 2023, 51 (1) 29-37; DOI: https://doi.org/10.1124/dmd.121.000624
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  A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine

  Yasuhiro Uno, Shiori Jikuya, Yutaro Noda, Norie Murayama and Hiroshi Yamazaki

  Drug Metabolism and Disposition January 2023, 51 (1) 38-45; DOI: https://doi.org/10.1124/dmd.121.000749
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  Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome Mapping Technology

  Xinxin Ding, John Han, Laura S. Van Winkle and Qing-Yu Zhang

  Drug Metabolism and Disposition January 2023, 51 (1) 46-53; DOI: https://doi.org/10.1124/dmd.122.001090
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  Stereoselective Metabolism of Bupropion to Active Metabolites in Cellular Fractions of Human Liver and Intestine

  Nadia O Bamfo, Jessica BL Lu and Zeruesenay Desta

  Drug Metabolism and Disposition January 2023, 51 (1) 54-66; DOI: https://doi.org/10.1124/dmd.122.000867
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  Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na_V1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver

  Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari

  Drug Metabolism and Disposition January 2023, 51 (1) 67-80; DOI: https://doi.org/10.1124/dmd.122.001000
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  Sexual Dimorphism in the Expression of Cytochrome P450 Enzymes in Rat Heart, Liver, Kidney, Lung, Brain, and Small Intestine

  Samar H. Gerges and Ayman O.S. El-Kadi

  Drug Metabolism and Disposition January 2023, 51 (1) 81-94; DOI: https://doi.org/10.1124/dmd.122.000915
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  Gut Microbiome–Wide Search for Bacterial Azoreductases Reveals Potentially Uncharacterized Azoreductases Encoded in the Human Gut Microbiome

  Domenick J. Braccia, Glory Minabou Ndjite, Ashley Weiss, Sophia Levy, Stephenie Abeysinghe, Xiaofang Jiang, Mihai Pop and Brantley Hall

  Drug Metabolism and Disposition January 2023, 51 (1) 142-153; DOI: https://doi.org/10.1124/dmd.122.000898