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Research ArticleArticle

Gut Microbiome–Wide Search for Bacterial Azoreductases Reveals Potentially Uncharacterized Azoreductases Encoded in the Human Gut Microbiome

Domenick J. Braccia, Glory Minabou Ndjite, Ashley Weiss, Sophia Levy, Stephenie Abeysinghe, Xiaofang Jiang, Mihai Pop and Brantley Hall
Drug Metabolism and Disposition January 2023, 51 (1) 142-153; DOI: https://doi.org/10.1124/dmd.122.000898
Domenick J. Braccia
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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  • ORCID record for Domenick J. Braccia
Glory Minabou Ndjite
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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Ashley Weiss
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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Sophia Levy
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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Stephenie Abeysinghe
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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Xiaofang Jiang
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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Mihai Pop
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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Brantley Hall
Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
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Article Information

vol. 51 no. 1 142-153
DOI 
https://doi.org/10.1124/dmd.122.000898
PubMed 
36116790

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 14, 2022
  • Accepted August 18, 2022
  • Published online December 29, 2022.

Article Versions

  • Earlier version (September 18, 2022 - 03:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Domenick J. Braccia,
  2. Glory Minabou Ndjite,
  3. Ashley Weiss,
  4. Sophia Levy,
  5. Stephenie Abeysinghe,
  6. Xiaofang Jiang,
  7. Mihai Pop, and
  8. Brantley Hall
  1. Center for Bioinformatics and Computational Biology (D.B., M.P., B.H.) and Departments of Cell Biology and Molecular Genetics (G.M.N., A.W., S.L., S.A., B.H.) and Computer Science (M.P.), University of Maryland, College Park, Maryland; and National Library of Medicine, National Institutes of Health, Bethesda, Maryland (X.J.)
  1. Address correspondence to:
    Dr. Brantley Hall, Bioscience Research Building, Room 3219, 3126 Campus Drive, College Park, MD 20742. E-mail: brantley{at}umd.edu
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Drug Metabolism and Disposition: 51 (1)
Drug Metabolism and Disposition
Vol. 51, Issue 1
1 Jan 2023
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Research ArticleArticle

Prediction of Uncharacterized Azo Reduction by the Gut Microbiome

Domenick J. Braccia, Glory Minabou Ndjite, Ashley Weiss, Sophia Levy, Stephenie Abeysinghe, Xiaofang Jiang, Mihai Pop and Brantley Hall
Drug Metabolism and Disposition January 1, 2023, 51 (1) 142-153; DOI: https://doi.org/10.1124/dmd.122.000898

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Research ArticleArticle

Prediction of Uncharacterized Azo Reduction by the Gut Microbiome

Domenick J. Braccia, Glory Minabou Ndjite, Ashley Weiss, Sophia Levy, Stephenie Abeysinghe, Xiaofang Jiang, Mihai Pop and Brantley Hall
Drug Metabolism and Disposition January 1, 2023, 51 (1) 142-153; DOI: https://doi.org/10.1124/dmd.122.000898
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