Table of Contents

Articles

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  The Utility of Mixed Effects Models in the Evaluation of Complex Genomic Traits In Vitro

  Nathan Alade, Abhinav Nath, Nina Isoherranen and Kenneth E. Thummel

  Drug Metabolism and Disposition November 2023, 51 (11) 1455-1462; DOI: https://doi.org/10.1124/dmd.123.001260
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  Exploring the Boundaries for In Vitro–In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types

  Laura Francis, Kayode Ogungbenro, Tom De Bruyn, J. Brian Houston and David Hallifax

  Drug Metabolism and Disposition November 2023, 51 (11) 1463-1473; DOI: https://doi.org/10.1124/dmd.123.001309
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  CYP2D6 Activity Is Correlated with Changes in Plasma Concentrations of Taurocholic Acid during Pregnancy and Postpartum in CYP2D6 Extensive Metabolizers

  Lindsay C. Czuba, Karan Malhotra, Luke Enthoven, Emily E. Fay, Sue L. Moreni, Jennie Mao, Yuanyuan Shi, Weize Huang, Rheem A. Totah, Nina Isoherranen and Mary F. Hebert

  Drug Metabolism and Disposition November 2023, 51 (11) 1474-1482; DOI: https://doi.org/10.1124/dmd.123.001358
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  Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice

  Victoria O. Oyanna, Kenisha Y. Garcia-Torres, Baron J. Bechtold, Katherine D. Lynch, M. Ridge Call, Miklós Horváth, Preston K. Manwill, Tyler N. Graf, Nadja B. Cech, Nicholas H. Oberlies, Mary F. Paine and John D. Clarke

  Drug Metabolism and Disposition November 2023, 51 (11) 1483-1489; DOI: https://doi.org/10.1124/dmd.123.001360
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  Human Carboxylesterase 1A Plays a Predominant Role in Hydrolysis of the Anti-Dyslipidemia Agent Fenofibrate in Humans

  Hong-Xin Li, Meng-Ru Sun, Ya Zhang, Li-Lin Song, Feng Zhang, Yun-Qing Song, Xu-Dong Hou and Guang-Bo Ge

  Drug Metabolism and Disposition November 2023, 51 (11) 1490-1498; DOI: https://doi.org/10.1124/dmd.123.001365
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  Heterodimerization of Human UDP-Glucuronosyltransferase 1A9 and UDP-Glucuronosyltransferase 2B7 Alters Their Glucuronidation Activities

  Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang and Su Zeng

  Drug Metabolism and Disposition November 2023, 51 (11) 1499-1507; DOI: https://doi.org/10.1124/dmd.123.001369
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  A Comprehensive Evaluation of the Effects of RNA-Editing Proteins ADAR and ADARB1 on the Expression of the Drug-Metabolizing Enzymes in HepaRG Cells

  Joseph M. Collins and Danxin Wang

  Drug Metabolism and Disposition November 2023, 51 (11) 1508-1514; DOI: https://doi.org/10.1124/dmd.123.001396
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  Prediction of Drug–Drug Interactions with Ensartinib as a Time-Dependent CYP3A Inhibitor Using Physiologically Based Pharmacokinetic Model

  Xiaowen Wang, Yiqun Yu, Hongrui Liu, Fengjiao Bu, Chunying Shen, Qingfeng He, Xiao Zhu, Pin Jiang, Bing Han and Xiaoqiang Xiang

  Drug Metabolism and Disposition November 2023, 51 (11) 1515-1526; DOI: https://doi.org/10.1124/dmd.123.001373
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  Potentiation of the Uricosuric Effect of Dotinurad by Trans-Inhibition of the Uric Acid Reabsorptive Transporter 1

  Kazuki Fujita, Qiunan Zhu, Hiroshi Arakawa, Yoshiyuki Shirasaka and Ikumi Tamai

  Drug Metabolism and Disposition November 2023, 51 (11) 1527-1535; DOI: https://doi.org/10.1124/dmd.123.001412
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  Pharmacokinetics and Absorption, Distribution, Metabolism and Excretion of RGLS4326 in Mouse and Monkey, an Anti–miR-17 Oligonucleotide for the Treatment of Polycystic Kidney Disease

  Amin Kamel, Tate Owen, Izaiah Cole, Tania Valencia and Edmund C. Lee

  Drug Metabolism and Disposition November 2023, 51 (11) 1536-1546; DOI: https://doi.org/10.1124/dmd.123.001446