Table of Contents

Articles

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  Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation

  Yu Sato, Eiji Hishinuma, Shuki Yamazaki, Akiko Ueda, Masaki Kumondai, Sakae Saito, Shu Tadaka, Kengo Kinoshita, Tomoki Nakayoshi, Akifumi Oda, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa and Masahiro Hiratsuka

  Drug Metabolism and Disposition December 2023, 51 (12) 1561-1568; DOI: https://doi.org/10.1124/dmd.123.001389
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  Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine

  Keiya Hirosawa, Hijiri Fujioka, Gaku Morinaga, Tatsuki Fukami, Naoki Ishiguro, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi and Miki Nakajima

  Drug Metabolism and Disposition December 2023, 51 (12) 1569-1577; DOI: https://doi.org/10.1124/dmd.123.001402
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  Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver

  Stephani L. Stancil, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder

  Drug Metabolism and Disposition December 2023, 51 (12) 1578-1582; DOI: https://doi.org/10.1124/dmd.123.001417
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  The Effects of Drug Exposure and Single Nucleotide Polymorphisms on Aaptinib-Induced Severe Toxicities in Solid Tumors

  Youhao Chen, Yaobin Lin, Shaoxing Guan, Zerui Zhao, Daren Lin, Jin Guan, Chengzhi Zhou, Junling Liu, Xiaolong Cao, Zhichao Lin, Diyao Chen, Jianbiao Shang, Weijian Zhang, Huohui Chen, Likun Chen, Shudong Ma, Lijia Gu, Jian Zhao, Min Huang, Xueding Wang and Hao Long

  Drug Metabolism and Disposition December 2023, 51 (12) 1583-1590; DOI: https://doi.org/10.1124/dmd.123.001428
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  Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation

  Nihan Izat, Jayaprakasam Bolleddula, Armina Abbasi, Lionel Cheruzel, Robert S. Jones, Darren Moss, Fatima Ortega-Muro, Yannick Parmentier, Vincent C. Peterkin, Dan-Dan Tian, Karthik Venkatakrishnan, Michael A. Zientek, Jill Barber, J. Brian Houston, Aleksandra Galetin and Daniel Scotcher

  Drug Metabolism and Disposition December 2023, 51 (12) 1591-1606; DOI: https://doi.org/10.1124/dmd.123.001436
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  Characterization of Pharmacokinetics, Biotransformation and Elimination of Pomotrelvir Orally Administered in Healthy Male Adults Using Two [¹⁴C]-Labeled Microtracers with Separate Labeling Positions

  Ziping Yang, Shekman L. Wong, David Cha, David Wilfret, David Turnquist, Andrew Plummer, Eric van Ingen and Brian P. Kearney

  Drug Metabolism and Disposition December 2023, 51 (12) 1607-1614; DOI: https://doi.org/10.1124/dmd.123.001439
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  Identification and Validation of Active Ingredient in Cerebrotein Hydrolysate-I Based on Pharmacokinetic and Pharmacodynamic Studies

  Huimin Guo, Huizhu Yang, Chanjuan Di, Feng Xu, Hong Sun, Yexin Xu, Huafang Liu, Linlin Wu, Ke Ding, Tingting Zhang, Lin Xie, Guangji Wang and Yan Liang

  Drug Metabolism and Disposition December 2023, 51 (12) 1615-1627; DOI: https://doi.org/10.1124/dmd.123.001443
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  Bempedoic Acid Unveils Therapeutic Potential in Non-Alcoholic Fatty Liver Disease: Suppression of the Hepatic PXR-SLC13A5/ACLY Signaling Axis

  Qiushuang Sun, Yating Guo, Wenjun Hu, Mengdi Zhang, Shijiao Wang, Yuanyuan Lei, Haitao Meng, Ning Li, Pengfei Xu, Zhiyu Li, Haishu Lin, Fang Huang and Zhixia Qiu

  Drug Metabolism and Disposition December 2023, 51 (12) 1628-1641; DOI: https://doi.org/10.1124/dmd.123.001449
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  Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4

  Mei-Hui Hsu and Eric F. Johnson

  Drug Metabolism and Disposition December 2023, 51 (12) 1642-1650; DOI: https://doi.org/10.1124/dmd.123.001464
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  Activation of CYP3A by Accelerated Blood Clearance Phenomenon Potentiates the Hepatocellular Carcinoma-Targeting Therapeutic Effects of PEGylated Anticancer Prodrug Liposomes

  Xue Zhang, Jianquan Pan, Xi Ye, Yunna Chen, Lei Wang, Xiangyun Meng, Weidong Chen and Fengling Wang

  Drug Metabolism and Disposition December 2023, 51 (12) 1651-1662; DOI: https://doi.org/10.1124/dmd.123.001496