Table of Contents

Articles

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  Renal Transporter Alterations in Patients with Chronic Liver Diseases: Nonalcoholic Steatohepatitis, Alcohol-Associated, Viral Hepatitis, and Alcohol-Viral Combination

  Kayla L. Frost, Joseph L. Jilek, Shripad Sinari, Robert R. Klein, Dean Billheimer, Stephen H. Wright and Nathan J. Cherrington

  Drug Metabolism and Disposition February 2023, 51 (2) 155-164; DOI: https://doi.org/10.1124/dmd.122.001038
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  Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity

  Eiji Hishinuma, Yoko Narita, Evelyn Marie Gutiérrez Rico, Akiko Ueda, Kai Obuchi, Yoshikazu Tanaka, Sakae Saito, Shu Tadaka, Kengo Kinoshita, Masamitsu Maekawa, Nariyasu Mano, Tomoki Nakayoshi, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka

  Drug Metabolism and Disposition February 2023, 51 (2) 165-173; DOI: https://doi.org/10.1124/dmd.122.001045
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  Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes

  Kaoru Kobayashi, Genki Minegishi, Nina Kuriyama, Atsushi Miyajima, Satoshi Abe, Kanako Kazuki and Yasuhiro Kazuki

  Drug Metabolism and Disposition February 2023, 51 (2) 174-182; DOI: https://doi.org/10.1124/dmd.122.001087
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  Bioavailability and Pharmacokinetics of Endoxifen in Female Rats and Dogs: Evidence to Support the Use of Endoxifen to Overcome the Limitations of CYP2D6-Mediated Tamoxifen Metabolism

  Emily J. Koubek, Sarah A. Buhrow, Stephanie L. Safgren, Lee Jia, Matthew P. Goetz, Matthew M. Ames and Joel M. Reid

  Drug Metabolism and Disposition February 2023, 51 (2) 183-192; DOI: https://doi.org/10.1124/dmd.122.000929
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  Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants

  Jialin Liu, Suzanne Banuvar, Marlos Viana, Elena Barengolts, Shao-Nong Chen, Guido F. Pauli and Richard B. van Breemen

  Drug Metabolism and Disposition February 2023, 51 (2) 199-204; DOI: https://doi.org/10.1124/dmd.122.001050
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  Open Access

  Biotransformation of Trastuzumab and Pertuzumab in Breast Cancer Patients Assessed by Affinity Enrichment and Ion-Exchange Chromatography

  Oladapo Olaleye, Baubek Spanov, Peter Bults, Anna van der Voort, Natalia Govorukhina, Gabe S. Sonke, Peter Horvatovich, Nico C. van de Merbel and Rainer Bischoff

  Drug Metabolism and Disposition February 2023, 51 (2) 249-256; DOI: https://doi.org/10.1124/dmd.122.001094
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  A Physiological-Based Pharmacokinetic Model Embedded with a Target-Mediated Drug Disposition Mechanism Can Characterize Single-Dose Warfarin Pharmacokinetic Profiles in Subjects with Various CYP2C9 Genotypes under Different Cotreatments

  Shen Cheng, Darcy R. Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy

  Drug Metabolism and Disposition February 2023, 51 (2) 257-267; DOI: https://doi.org/10.1124/dmd.122.001048