Table of Contents

Articles

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  Maternal and Fetal Exposure to (-)-Δ⁹-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein and Breast Cancer Resistance Protein

  Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

  Drug Metabolism and Disposition March 2023, 51 (3) 269-275; DOI: https://doi.org/10.1124/dmd.122.001110
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  Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating Profiles

  Aynur Ekiciler, Wen Li Kelly Chen, Yan Bo, Alessandra Pugliano, Massimiliano Donzelli, Neil Parrott and Kenichi Umehara

  Drug Metabolism and Disposition March 2023, 51 (3) 276-284; DOI: https://doi.org/10.1124/dmd.122.001132
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  Quantification of Accurate Composition and Total Abundance of Homologous Proteins by Conserved-Plus-Surrogate Peptide Approach: Quantification of UDP Glucuronosyltransferases in Human Tissues

  Deepak Ahire, Mitesh Patel, Sujal V. Deshmukh and Bhagwat Prasad

  Drug Metabolism and Disposition March 2023, 51 (3) 285-292; DOI: https://doi.org/10.1124/dmd.122.001155
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  Open Access

  Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro

  Marie-Noëlle Paludetto, Mika Kurkela, Helinä Kahma, Janne T. Backman, Mikko Niemi and Anne M. Filppula

  Drug Metabolism and Disposition March 2023, 51 (3) 293-305; DOI: https://doi.org/10.1124/dmd.122.001018
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  Contribution of UGT Enzymes to Human Drug Metabolism Stereoselectivity: A Case Study of Medetomidine, RO5263397, Propranolol, and Testosterone

  Nicolò Milani, NaHong Qiu and Stephen Fowler

  Drug Metabolism and Disposition March 2023, 51 (3) 306-317; DOI: https://doi.org/10.1124/dmd.122.001024
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  Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption

  Aoi Yoshitomo, Satoshi Asano, Shizuka Hozuki, Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Keita Takahashi, Yoko Sasaki, Naoka Ozawa, Michiharu Kageyama, Takeshi Iijima, Yasuhiro Kazuki, Hiromi Sato and Akihiro Hisaka

  Drug Metabolism and Disposition March 2023, 51 (3) 318-328; DOI: https://doi.org/10.1124/dmd.122.000907
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  Pharmacokinetic/Pharmacodynamic Models of an Alzheimer’s Drug, Donepezil, in Rats

  Akiko Kiriyama, Shunsuke Kimura and Shugo Yamashita

  Drug Metabolism and Disposition March 2023, 51 (3) 329-337; DOI: https://doi.org/10.1124/dmd.122.001061
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  Comprehensive Analyses of the Intracellular and in Vivo Disposition of Fab– Small Interfering RNA Conjugate to Identify Key Issues to Improve Its in Vivo Activity

  Asami Toshima, Yasuhisa Shiraishi, Daisuke Shinmi, Yoshiyuki Kagawa and Junichi Enokizono

  Drug Metabolism and Disposition March 2023, 51 (3) 338-347; DOI: https://doi.org/10.1124/dmd.122.001098
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  Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody

  Amita Datta-Mannan, Bruce A. Molitoris, Yiqing Feng, Michelle M. Martinez, Ruben M. Sandoval, Robin M. Brown, Daniel Merkel, Johnny E. Croy and Kenneth W. Dunn

  Drug Metabolism and Disposition March 2023, 51 (3) 403-412; DOI: https://doi.org/10.1124/dmd.122.001049