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Drug Metabolism & Disposition

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Table of Contents

March 01, 2023; Volume 51,Issue 3

Special Section on Drug Metabolism and Precision Medicine

  • You have access
    Special Section on Drug Metabolism and Precision Medicine—Editorial
    Xiao-bo Zhong and Yurong Lai
    Drug Metabolism and Disposition March 2023, 51 (3) 348-349; DOI: https://doi.org/10.1124/dmd.122.001243
  • Open Access
    Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies
    Abigail M. Wheeler, Colten D. Eberhard, Eric P. Mosher, Yuting Yuan, Hannah N. Wilkins, Herana Kamal Seneviratne, Benjamin C. Orsburn and Namandjé N. Bumpus
    Drug Metabolism and Disposition March 2023, 51 (3) 350-359; DOI: https://doi.org/10.1124/dmd.122.001043
  • You have access
    Cell and Tissue Specific Metabolism of Nucleoside and Nucleotide Drugs: Case Studies and Implications for Precision Medicine
    Elaine E. To
    Drug Metabolism and Disposition March 2023, 51 (3) 360-368; DOI: https://doi.org/10.1124/dmd.122.000856
  • You have access
    Multidisciplinary Insights into the Structure–Function Relationship of the CYP2B6 Active Site
    Ethan D. Angle and Philip M. Cox
    Drug Metabolism and Disposition March 2023, 51 (3) 369-384; DOI: https://doi.org/10.1124/dmd.122.000853
  • You have access
    Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate
    Herana Kamal Seneviratne
    Drug Metabolism and Disposition March 2023, 51 (3) 385-391; DOI: https://doi.org/10.1124/dmd.122.000855

Minireview

  • You have access
    Opportunities for Accelerating Drug Discovery and Development by Using Engineered Drug-Metabolizing Enzymes
    Elizabeth M.J. Gillam and Valerie M. Kramlinger
    Drug Metabolism and Disposition March 2023, 51 (3) 392-402; DOI: https://doi.org/10.1124/dmd.121.000743

Articles

  • You have access
    Maternal and Fetal Exposure to (-)-Δ9-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein and Breast Cancer Resistance Protein
    Xin Chen, Jashvant D. Unadkat and Qingcheng Mao
    Drug Metabolism and Disposition March 2023, 51 (3) 269-275; DOI: https://doi.org/10.1124/dmd.122.001110
  • You have access
    Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating Profiles
    Aynur Ekiciler, Wen Li Kelly Chen, Yan Bo, Alessandra Pugliano, Massimiliano Donzelli, Neil Parrott and Kenichi Umehara
    Drug Metabolism and Disposition March 2023, 51 (3) 276-284; DOI: https://doi.org/10.1124/dmd.122.001132
  • You have access
    Quantification of Accurate Composition and Total Abundance of Homologous Proteins by Conserved-Plus-Surrogate Peptide Approach: Quantification of UDP Glucuronosyltransferases in Human Tissues
    Deepak Ahire, Mitesh Patel, Sujal V. Deshmukh and Bhagwat Prasad
    Drug Metabolism and Disposition March 2023, 51 (3) 285-292; DOI: https://doi.org/10.1124/dmd.122.001155
  • Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A <em>in vitro</em>
    Open Access
    Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro
    Marie-Noëlle Paludetto, Mika Kurkela, Helinä Kahma, Janne T. Backman, Mikko Niemi and Anne M. Filppula
    Drug Metabolism and Disposition March 2023, 51 (3) 293-305; DOI: https://doi.org/10.1124/dmd.122.001018
  • You have access
    Contribution of UGT Enzymes to Human Drug Metabolism Stereoselectivity: A Case Study of Medetomidine, RO5263397, Propranolol, and Testosterone
    Nicolò Milani, NaHong Qiu and Stephen Fowler
    Drug Metabolism and Disposition March 2023, 51 (3) 306-317; DOI: https://doi.org/10.1124/dmd.122.001024
  • Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption
    You have access
    Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption
    Aoi Yoshitomo, Satoshi Asano, Shizuka Hozuki, Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Keita Takahashi, Yoko Sasaki, Naoka Ozawa, Michiharu Kageyama, Takeshi Iijima, Yasuhiro Kazuki, Hiromi Sato and Akihiro Hisaka
    Drug Metabolism and Disposition March 2023, 51 (3) 318-328; DOI: https://doi.org/10.1124/dmd.122.000907
  • Pharmacokinetic/Pharmacodynamic Models of an Alzheimer’s Drug, Donepezil, in Rats
    You have access
    Pharmacokinetic/Pharmacodynamic Models of an Alzheimer’s Drug, Donepezil, in Rats
    Akiko Kiriyama, Shunsuke Kimura and Shugo Yamashita
    Drug Metabolism and Disposition March 2023, 51 (3) 329-337; DOI: https://doi.org/10.1124/dmd.122.001061
  • Comprehensive Analyses of the Intracellular and in Vivo Disposition of Fab– Small Interfering RNA Conjugate to Identify Key Issues to Improve Its in Vivo Activity
    You have access
    Comprehensive Analyses of the Intracellular and in Vivo Disposition of Fab– Small Interfering RNA Conjugate to Identify Key Issues to Improve Its in Vivo Activity
    Asami Toshima, Yasuhisa Shiraishi, Daisuke Shinmi, Yoshiyuki Kagawa and Junichi Enokizono
    Drug Metabolism and Disposition March 2023, 51 (3) 338-347; DOI: https://doi.org/10.1124/dmd.122.001098
  • Open Access
    Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody
    Amita Datta-Mannan, Bruce A. Molitoris, Yiqing Feng, Michelle M. Martinez, Ruben M. Sandoval, Robin M. Brown, Daniel Merkel, Johnny E. Croy and Kenneth W. Dunn
    Drug Metabolism and Disposition March 2023, 51 (3) 403-412; DOI: https://doi.org/10.1124/dmd.122.001049
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In this issue

Drug Metabolism and Disposition: 51 (3)
Drug Metabolism and Disposition
Vol. 51, Issue 3
1 Mar 2023
  • Table of Contents
  • Table of Contents (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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