Table of Contents

Articles

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  Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition

  Abdul Basit, John K. Amory, Vijaya Saradhi Mettu, Cindy Yanfei Li, Scott Heyward, Parth B. Jariwala, Matthew R. Redinbo and Bhagwat Prasad

  Drug Metabolism and Disposition April 2023, 51 (4) 427-435; DOI: https://doi.org/10.1124/dmd.122.000975
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  Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-Sparing PI3K Inhibitor in Rats, Dogs, and Humans

  Shuguang Ma, Sungjoon Cho, Srikumar Sahasranaman, Weiping Zhao, Jodie Pang, Xiao Ding, Brian Dean, Bin Wang, Jerry Y. Hsu, Joseph Ware and Laurent Salphati

  Drug Metabolism and Disposition April 2023, 51 (4) 436-450; DOI: https://doi.org/10.1124/dmd.122.001096
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  Open Access

  Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans

  Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf and V. Sashi Gopaul

  Drug Metabolism and Disposition April 2023, 51 (4) 451-463; DOI: https://doi.org/10.1124/dmd.122.001100
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  Open Access

  Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans

  Ulrik Jurva, Lars Weidolf, Ann-Sofie Sandinge, Carina Leandersson, Anja Ekdahl, Xue-Qing Li, Thomas Antonsson, Johan Sundell, Kristina Westerlund, Carl Amilon, Tord Inghardt and V. Sashi Gopaul

  Drug Metabolism and Disposition April 2023, 51 (4) 464-479; DOI: https://doi.org/10.1124/dmd.122.001099
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  The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers

  Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki and Hiroshi Suemizu

  Drug Metabolism and Disposition April 2023, 51 (4) 480-491; DOI: https://doi.org/10.1124/dmd.122.001102
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  CYP3A4 and CYP3A5 Expression is Regulated by CYP3A4*1G in CRISPR/Cas9-Edited HepG2 Cells

  Weihong Yang, Huan Zhao, Yaojie Dou, Pei Wang, Qi Chang, Xiaomeng Qiao, Xiaofei Wang, Chen Xu, Zhe Zhang and Lirong Zhang

  Drug Metabolism and Disposition April 2023, 51 (4) 492-498; DOI: https://doi.org/10.1124/dmd.122.001111
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  Predictive Performance of Physiologically Based Pharmacokinetic Modelling of Beta-Lactam Antibiotic Concentrations in Adipose, Bone, and Muscle Tissues

  Pieter-Jan De Sutter, Pieter De Cock, Trevor N Johnson, Helen Musther, Elke Gasthuys and An Vermeulen

  Drug Metabolism and Disposition April 2023, 51 (4) 499-508; DOI: https://doi.org/10.1124/dmd.122.001129
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  Antibiotics-Induced Depletion of Rat Microbiota Induces Changes in the Expression of Host Drug-Processing Genes and Pharmacokinetic Behaviors of CYPs Probe Drugs

  Haijun Yang, Yanjuan Zhang, Rong Zhou, Tianyuan Wu, Peng Zhu, Yujie Liu, Jian Zhou, Yalan Xiong, Yanling Xiong, Honghao Zhou, Wei Zhang, Yan Shu, Xiong Li and Qing Li

  Drug Metabolism and Disposition April 2023, 51 (4) 509-520; DOI: https://doi.org/10.1124/dmd.122.001173
• Open Access

  Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems

  Abigail M. Wheeler, Benjamin C. Orsburn and Namandjé N. Bumpus

  Drug Metabolism and Disposition April 2023, 51 (4) 521-531; DOI: https://doi.org/10.1124/dmd.122.001195