Taselisib | Parent | 0.575 | 72.1 | 4.90 | 0.259 | 24.8 | 32.1 | 12.3 | 71.9 |
M1 | Oxidation (+32 Da) | 0.040 | ND | 0.995 | ND | ND | ND | ND | ND |
M2 | Glutathione conjugation | ND | ND | 0.550 | ND | ND | ND | ND | ND |
M3 | Oxidation (+16 Da) | ND | ND | 0.640 | ND | ND | ND | ND | ND |
M4 | Oxidation and glucuronidation | ND | ND | 0.760 | ND | ND | ND | ND | ND |
M5 | Di-oxidation (+32 Da) | ND | 2.74 | 0.260 | ND | ND | ND | ND | 2.65 |
M6 | Oxidative ring opening | ND | ND | 0.215 | ND | ND | ND | ND | 1.44 |
M7 | Oxidation and sulfation | ND | ND | 0.175 | ND | ND | ND | ND | ND |
M8 | Oxidation (+16 Da) | 0.100 | ND | ND | ND | ND | ND | ND | ND |
M9 | Amide hydrolysis | ND | 2.39 | 7.13 | 0.516 | 15.7 | 9.08 | 0.825 | 8.55 |
M10 | Oxidation (+16 Da) | 1.760 | 15.5 | 3.07 | 0.258 | 6.10 | 1.89 | 0.697 | 0.868 |
M11 | Oxidation (+16 Da) | 0.230 | 1.78 | 0.31 | 0.622 | 7.09 | 4.79 | 1.23 | 1.42 |
M12 | Acetylation and ring opening | ND | ND | 0.152 | ND | ND | ND | ND | ND |
M13 | Oxidation and glucuronidation | D | D | D | ND | ND | ND | ND | ND |
M14 | Methylation and oxidation | ND | ND | ND | 0.008 | 0.374 | D | ND | ND |
M15 | Methylation and hydrolysis | ND | ND | ND | 0.082 | 0.346 | D | ND | ND |
M16 | Methylation and oxidation | ND | ND | ND | 0.090 | 11.2 | 2.95 | ND | ND |
M17 | Methylation | ND | ND | ND | 0.222 | 29.5 | 18.1 | ND | ND |
% Dose subtotal | | 2.68 | 94.5 | 19.1 | 2.06 | 95.1 | 68.9 | 15.0 | 86.9 |
% Total excretion | | 4.27 | 97.1 | 21.2 | 2.32 | 95.1 | 68.9 | 15.0 | 88.5 |