52 phase I enzymes | 8 enzymes involved in hydrolysis reactions | CES1D | | CES1D, 1E, 2C, 2G | |
PON1, 3 | | | |
EPHX1 | | EPHX1 | |
AADAC | | AADAC | |
12 enzymes involved in reduction reactions | AKR7A2, 1C1, 1C2, 1C12, 1C13, 1C19 | | AKR7A2, 1C19, 1E2 | |
| NQO1 | | |
| | CBR3 | |
CYB5A, 5R3 | CYB5B | | |
22 CYP family | CYP2A1, 2C11, 2C13, 2C23, 2D2, 2D3, 2E1, 2F4, 2J4, 2J10, 2T1, 3A18, 3A23/3A1, 4B1, 4F1, 4F6 | CYP2B2, 2C7, 2C12 | CYP2E1, 4F39 | CYP1B1, 4V3 |
10 non-P450 enzymes | ADH6, FE1 | | ADHFE1 | |
ALDH2 | ALDH1B1, 1L2 | ALDH1B1 | |
FMO1, 3 | FMO5 | FMO1 | |
AOX1, 4 | | AOX1 | |
30 phase II enzymes | 16 Gsts | GSTA1, A2, A3, A6, K1, M1, M6, M7, O1, P1, T1, T3, Z1 | | GSTA3, A5, M4, M6L, O1, P1 | |
2 Ugts | UGT2B35 | UGT2B10 | | |
5 Sults | SULT1A1, 1B1, 1C2, 1C2A, 1E1 | | | |
1 Nat | | | NAT8L | |
3 methyltransferases | INMT, GAMT | | TPMT | |
3 amino acid conjugation enzymes | ACNAT2, BAAT, GLYAT | | | |
30 transporters | 16 uptake | GLUT2, OATP2, MCT4, MCT11 | PHT1, GLUT6, OATP3A1, MCT1, TAT1, MCT12, SLC10A5, P7, y+LAT1, CAT2 | OCT3 | GLUT12 |
14 efflux | ABCR, SUR | ABCA3, ABCA5, ABCA8, ABCB7, ABCB10, BSEP, MRP4 | ABCC10, ABC50 | ABC2, MRP1, MRP4, SUR, SUR2 |
4 TFs | | PXR | PPARα, RXRα | HNF1α | |