Research ArticleArticle
Detection and Characterization of In Vitro Payload-Containing Catabolites of Noncleavable Antibody-Drug Conjugates by High-Resolution Mass Spectrometry and Multiple Data Mining Tools
Tingting Cai, Liqi Shi, Huihui Guo, Ruixing Li, Weiqun Cao, Liang Shen, Mingshe Zhu and Yi Tao
Drug Metabolism and Disposition May 2023, 51 (5) 591-598; DOI: https://doi.org/10.1124/dmd.122.001135
Tingting Cai
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
Liqi Shi
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
Huihui Guo
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
Ruixing Li
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
Weiqun Cao
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
Liang Shen
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
Mingshe Zhu
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
Yi Tao
Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Nanjing, Jiangsu, China (T.C.); Drug Metabolism and Pharmacokinetic Services, WuXi AppTec, Shanghai, China (L.S., R.L., W.C., L.S., Y.T.); Hangzhou DAC Biotechnology Co., Ltd., Hangzhou, China (H.G.); and MassDefect Technologies, Princeton, New Jersey (M.Z.)
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In this issue
Research ArticleArticle
Identification of Payload-Containing Catabolites of ADCs
Tingting Cai, Liqi Shi, Huihui Guo, Ruixing Li, Weiqun Cao, Liang Shen, Mingshe Zhu and Yi Tao
Drug Metabolism and Disposition May 1, 2023, 51 (5) 591-598; DOI: https://doi.org/10.1124/dmd.122.001135
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