Table of Contents

Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development

50th Anniversary Celebration Collection

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  Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development—Editorial

  Yurong Lai and Xiao-bo Zhong

  Drug Metabolism and Disposition September 2023, 51 (9) 1064-1066; DOI: https://doi.org/10.1124/dmd.123.001456
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  A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept

  Yuichi Sugiyama and Yasunori Aoki

  Drug Metabolism and Disposition September 2023, 51 (9) 1067-1076; DOI: https://doi.org/10.1124/dmd.123.001344
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  Preincubation Time-Dependent, Long-Lasting Inhibition of Drug Transporters and Impact on the Prediction of Drug−Drug Interactions

  Yoshitane Nozaki and Saki Izumi

  Drug Metabolism and Disposition September 2023, 51 (9) 1077-1088; DOI: https://doi.org/10.1124/dmd.122.000970
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  Evaluation of the Selectivity of Several Organic Anion Transporting Polypeptide 1B Biomarkers Using Relative Activity Factor Method

  Grace Hoyee Chan, Robert Houle, Jinghui Zhang, Ravi Katwaru, Yang Li and Xiaoyan Chu

  Drug Metabolism and Disposition September 2023, 51 (9) 1089-1104; DOI: https://doi.org/10.1124/dmd.122.000972
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  Progress in the Quantitative Assessment of Transporter-Mediated Drug–Drug Interactions Using Endogenous Substrates in Clinical Studies

  Tatsuki Mochizuki and Hiroyuki Kusuhara

  Drug Metabolism and Disposition September 2023, 51 (9) 1105-1113; DOI: https://doi.org/10.1124/dmd.123.001285
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  Quantitative Consideration of Clinical Increases in Serum Creatinine Caused by Renal Transporter Inhibition

  Tomohisa Nakada, Toshiyuki Kudo and Kiyomi Ito

  Drug Metabolism and Disposition September 2023, 51 (9) 1114-1126; DOI: https://doi.org/10.1124/dmd.122.000969
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  Emerging Roles of Uremic Toxins and Inflammatory Cytokines in the Alteration of Hepatic Drug Disposition in Patients with Kidney Dysfunction

  Hiroshi Arakawa and Yukio Kato

  Drug Metabolism and Disposition September 2023, 51 (9) 1127-1135; DOI: https://doi.org/10.1124/dmd.122.000967
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  Quantitative Prediction of Intestinal Absorption of Drugs from In Vitro Study: Utilization of Differentiated Intestinal Epithelial Cells Derived from Intestinal Stem Cells at Crypts

  Kazuya Maeda

  Drug Metabolism and Disposition September 2023, 51 (9) 1136-1144; DOI: https://doi.org/10.1124/dmd.122.000966
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  Predicting In Vivo Target Occupancy (TO) Profiles via Physiologically Based Pharmacokinetic–TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and Prediction of Stereoselective Target Interactions

  Wooin Lee, Min-Soo Kim, Jiyoung Kim, Yasunori Aoki and Yuichi Sugiyama

  Drug Metabolism and Disposition September 2023, 51 (9) 1145-1156; DOI: https://doi.org/10.1124/dmd.122.000968