The Potentially Significant Role of CYP3A-Mediated Oxidative Metabolism of Dabigatran Etexilate and Its Intermediate Metabolites in Drug-Drug Interaction Assessments Using Microdose Dabigatran Etexilate

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences (U.U., S.J.) and Chulalongkorn University Drug Discovery and Drug Development Research Center (Chula4DR) (U.U., T.P.), Chulalongkorn University, Bangkok, Thailand

Address correspondence to:
Thomayant Prueksaritanont, Chulalongkorn University Drug Discovery and Drug Development Research Center (Chula4DR), Chulalongkorn University, 254 Phayathai Rd., Wangmai, Pathumwan, Bangkok 10330, Thailand. E-mail: thomayant.p{at}pharm.chula.ac.th; or Suree Jianmongkol, Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Rd., Wangmai, Pathumwan, Bangkok 10330, Thailand. E-mail: suree.j{at}pharm.chula.ac.th