Table of Contents

Articles

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  Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver

  Sandhya Subash and Bhagwat Prasad

  Drug Metabolism and Disposition December 2024, 52 (12) 1363-1372; DOI: https://doi.org/10.1124/dmd.124.001608
• Open Access

  Utility of Common In Vitro Systems for Predicting Circulating Metabolites

  Elyse C. Freiberger, Michael P. Thompson, Xiaomei Zhang, Essence B. Underwood, Thomas L. Lynch, Gary J. Jenkins and David S. Wagner

  Drug Metabolism and Disposition December 2024, 52 (12) 1373-1378; DOI: https://doi.org/10.1124/dmd.124.001732
• Open Access

  Absorption, Distribution, Metabolism, and Excretion of Icenticaftor (QBW251) in Healthy Male Volunteers at Steady State and In Vitro Phenotyping of Major Metabolites

  Ulrike Glaenzel, Felix Huth, Fabian Eggimann, Melissa Hackling, Luc Alexis Leuthold, Axel Meissner and Lidiya Bebrevska

  Drug Metabolism and Disposition December 2024, 52 (12) 1379-1387; DOI: https://doi.org/10.1124/dmd.124.001751
• Open Access

  Candesartan Has No Clinically Meaningful Effect on the Plasma Concentrations of Cytochrome P450 2C8 Substrate Repaglinide in Humans

  Mikael O.W. Piha, Kristiina Cajanus, Marica T. Engström, Mikko Neuvonen, Troels K. Bergmann, Mikko Niemi, Janne T. Backman, Anne M. Filppula and Aleksi Tornio

  Drug Metabolism and Disposition December 2024, 52 (12) 1388-1395; DOI: https://doi.org/10.1124/dmd.124.001798
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  Open Access

  Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, a Novel Drug Class for Duchenne Muscular Dystrophy

  Andrew K.L. Goey, Marie Claire Mukashyaka, Yogesh Patel, Louise R. Rodino-Klapac and Lilly East

  Drug Metabolism and Disposition December 2024, 52 (12) 1396-1406; DOI: https://doi.org/10.1124/dmd.124.001819
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  3-epi-18β-Glycyrrhetinic Acid or Its Glucuronide, the Metabolites of Glycyrrhizinic Acid with Individual Differences, Correlated with Diagnostic Marker for Licorice-Induced Pseudoaldosteronism in Humans

  Ryota Sakoda, Kan’ichiro Ishiuchi, Tetsuhiro Yoshino, Yuna Tsunoo, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Koichi Fukunaga, Kenji Watanabe and Toshiaki Makino

  Drug Metabolism and Disposition December 2024, 52 (12) 1407-1416; DOI: https://doi.org/10.1124/dmd.124.001840
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  Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites

  Brayden D. Whitlock, Yingze Ma, Gwenaëlle Conseil, Alicia R. O’Brien, Mayukh Banerjee, Diane P. Swanlund, Z. Ping Lin, Yao Wang, X. Chris Le, John D. Schuetz, Susan P.C. Cole and Elaine M. Leslie

  Drug Metabolism and Disposition December 2024, 52 (12) 1417-1428; DOI: https://doi.org/10.1124/dmd.124.001852
• Open Access

  CYP P450 and non-CYP P450 Drug Metabolizing Enzyme Families Exhibit Differential Sensitivities towards Proinflammatory Cytokine Modulation

  Laura M. de Jong, Chandan Harpal, Dirk-Jan van den Berg, Menno Hoekstra, Nienke J. Peter, Robert Rissmann, Jesse J. Swen and Martijn L. Manson

  Drug Metabolism and Disposition December 2024, 52 (12) 1429-1437; DOI: https://doi.org/10.1124/dmd.124.001867
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  Quantitative Prediction of Drug-Drug Interactions Caused by CYP3A Induction Using Endogenous Biomarker 4β-Hydroxycholesterol

  Hiroaki Takubo, Toshio Taniguchi and Yukihiro Nomura

  Drug Metabolism and Disposition December 2024, 52 (12) 1438-1444; DOI: https://doi.org/10.1124/dmd.124.001876