Table of Contents

Articles

• Open Access

  A Phase I Study To Determine the Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Capivasertib in Healthy Male Participants

  Claire Miller, Martin Wild, Zhoupeng Zhang, Roberto Sommavilla, Don Shanahan, Christopher Bailey, Malin Gränfors, Ryan A. Bragg, Jin Dong, Sharan Sidhu and Marie Cullberg

  Drug Metabolism and Disposition September 2024, 52 (9) 939-948; DOI: https://doi.org/10.1124/dmd.124.001636
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  Cytochrome P450 and UDP-Glucuronosyltransferase Expressions, Activities, and Induction Abilities in 3D-Cultured Human Renal Proximal Tubule Epithelial Cells

  Shiori Hashiba, Masataka Nakano, Itsuki Yokoseki, Etsushi Takahashi, Masayuki Kondo, Yoichi Jimbo, Naoki Ishiguro, Hiroshi Arakawa, Tatsuki Fukami and Miki Nakajima

  Drug Metabolism and Disposition September 2024, 52 (9) 949-956; DOI: https://doi.org/10.1124/dmd.124.001685
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  Impact of OATP2B1 on Pharmacokinetics of Atorvastatin Investigated in rSlco2b1-Knockout and SLCO2B1-Knockin Rats

  Jonny Kinzi, Janine Hussner, Isabell Seibert, Mirubagini Vythilingam, Celina Vonwyl, Clarisse Gherardi, Pascal Detampel, Oliver Schwardt, Daniel Ricklin and Henriette E. Meyer zu Schwabedissen

  Drug Metabolism and Disposition September 2024, 52 (9) 957-965; DOI: https://doi.org/10.1124/dmd.124.001686
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  1β-Hydroxydeoxycholic Acid as an Endogenous Biomarker in Human Plasma for Assessment of CYP3A Clinical Drug–Drug Interaction Potential

  Yongjun Xue, Linna Wang, Runlan Huo, Mu Chen, Brian Melo, Karen Dingley, Allison Gaudy and Jim X. Shen

  Drug Metabolism and Disposition September 2024, 52 (9) 966-974; DOI: https://doi.org/10.1124/dmd.124.001680
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  Investigating the Correlation between Genotypes and Hepatic Protein Expression of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 Using Postmortem Tissue from a Danish Population

  Kata W. Pedersen, Jeppe D. Andersen, Jakob Hansen, Claus Børsting, Jytte Banner, Jørgen B. Hasselstrøm and Jakob R. Jornil

  Drug Metabolism and Disposition September 2024, 52 (9) 975-980; DOI: https://doi.org/10.1124/dmd.124.001692
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  Discovery of Unprecedented Human Stercobilin Conjugates

  Sungjoon Cho, Lionel Cheruzel, Jingwei Cai, Stephen K. Wrigley, Renia T. Gemmell, Tetsuo Kokubun, Jonathan C. P. Steele, Laurent Salphati, Donglu Zhang and S. Cyrus Khojasteh

  Drug Metabolism and Disposition September 2024, 52 (9) 981-987; DOI: https://doi.org/10.1124/dmd.124.001725
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  Effects of the Thiol Methyltransferase Inhibitor (±)-2,3-Dichloro-α-Methylbenzylamine (DCMB) on the Pharmacokinetics and Metabolism of Vicagrel in Rats

  Cheng Yang, Jingru Gong, Mingzhen Xue, Wensi Huang, Yali Yuan, Chong Chen, Yifei He, Chen Yang, Hongbin Sun, Yongqiang Liu, Yanchun Gong, Yong Wu, Xiaojuan Lai, Dafang Zhong, Xingxing Diao, Huiping Lu and Yuandong Zheng

  Drug Metabolism and Disposition September 2024, 52 (9) 988-996; DOI: https://doi.org/10.1124/dmd.124.001739
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  SND1 Regulates Organic Anion Transporter 2 Protein Expression and Sensitivity of Hepatocellular Carcinoma Cells to 5-Fluorouracil

  Yu Wang, Yingying Wang, Yanyan Fang, Huidi Jiang, Lushan Yu, Haihong Hu and Su Zeng

  Drug Metabolism and Disposition September 2024, 52 (9) 997-1008; DOI: https://doi.org/10.1124/dmd.124.001757
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  Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11

  Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama and Hiroshi Yamazaki

  Drug Metabolism and Disposition September 2024, 52 (9) 1009-1019; DOI: https://doi.org/10.1124/dmd.124.001780
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  The Drug-Drug Interaction between Erlotinib and OSI-930 Is Mediated through Aldehyde Oxidase Inhibition

  Lloyd Wei Tat Tang, Yuanyuan Shi, Raman Sharma and R. Scott Obach

  Drug Metabolism and Disposition September 2024, 52 (9) 1020-1028; DOI: https://doi.org/10.1124/dmd.124.001802
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  The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients

  Shunji Imai, Naoki Watanabe, Yuichiro Tone, Rei Mitamura, Jumpei Mori, Tsubasa Kameyama, Tetsuhiro Yamada and Kazutomi Kusano

  Drug Metabolism and Disposition September 2024, 52 (9) 1029-1036; DOI: https://doi.org/10.1124/dmd.124.001806