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Drug Metabolism & Disposition

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Abstract

Species, sex, and developmental differences in the O- and N-dealkylation of ethylmorphine by hepatic microsomes.

D E Nerland and G J Mannering
Drug Metabolism and Disposition March 1978, 6 (2) 150-153;
D E Nerland
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G J Mannering
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Abstract

3-O-[1'-14C]Ethylmorphine and ethylmorphine, respectively, were used to measure O- and N-dealkylase activities of hepatic microsomes. The well-known sex difference in the rate of N-delakylation in mature rats was not observed with O-dealkylation, nor did O-dealkylase activity increase as male rats reached maturity, as is the case with N-dealkylase activity. Accordingly, O-dealkylation represents only about 20% of the total dealkylase activity (O- + N-) in mature male rats, but about 50% in mature female rats. A comparison of the O- and N-dealkylating activities of hepatic microsomes from rats, mice, guinea pigs, and rabbits showed that both the rates of O- and N-dealkylation and the ratio of the two reactions vary greatly among animal species. These studies contribute to the evidence that different cytochrome P-450-dependent mono-oxygenase systems are involved in the O- and N-dealkylation of opium alkaloids.

 

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Drug Metabolism and Disposition
Vol. 6, Issue 2
1 Mar 1978
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Abstract

Species, sex, and developmental differences in the O- and N-dealkylation of ethylmorphine by hepatic microsomes.

D E Nerland and G J Mannering
Drug Metabolism and Disposition March 1, 1978, 6 (2) 150-153;

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Abstract

Species, sex, and developmental differences in the O- and N-dealkylation of ethylmorphine by hepatic microsomes.

D E Nerland and G J Mannering
Drug Metabolism and Disposition March 1, 1978, 6 (2) 150-153;
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