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Drug Metabolism & Disposition

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Table of Contents

May 01, 1980; Volume 8,Issue 3
  • You have access
    Characterization of dog hepatic drug-metabolizing enzymes and resultant effects on benzo[a]pyrene metabolite pattern and mutagenicity.
    M D Golan, M Bücker, H U Schmassmann, D Raphael, R Jung, U Bindel, H O Brase, F Tegtmeyer, T Friedberg, J Lorenz, P Stasiecki and F Oesch
    Drug Metabolism and Disposition May 1980, 8 (3) 121-126; DOI: https://doi.org/10.1124/dmd.8.3.121
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    Metabolism and covalent binding of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p,'-DDD). Correlation between adrenocorticolytic activity and metabolic activation by adrenocortical mitochondria.
    F Martz and J A Straw
    Drug Metabolism and Disposition May 1980, 8 (3) 127-130; DOI: https://doi.org/10.1124/dmd.8.3.127
  • You have access
    Identification of a glutathione conjugate of cambendazole formed in the presence of liver microsomes.
    D E Wolf, J A VandenHeuvel, T R Tyler, R W Walker, F R Koniuszy, V Gruber, B H Arison, A Rosegay, T A Jacob and F J Wolf
    Drug Metabolism and Disposition May 1980, 8 (3) 131-136; DOI: https://doi.org/10.1124/dmd.8.3.131
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    4-Thio derivatives of cambendazole.
    A Rosegay
    Drug Metabolism and Disposition May 1980, 8 (3) 136-138; DOI: https://doi.org/10.1124/dmd.8.3.136
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    Inhibition of hepatic drug metabolism in VX2 carcinoma-bearing rabbits.
    M Weiner and J W Olson
    Drug Metabolism and Disposition May 1980, 8 (3) 139-142; DOI: https://doi.org/10.1124/dmd.8.3.139
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    Effect of acute and chronic estrone, estradiol, and estriol treatment on hepatic, pulmonary, and intestinal mixed-function mon-oxygenase activities in female rats.
    W A Al-Turk, S J Stohs and E B Roche
    Drug Metabolism and Disposition May 1980, 8 (3) 143-146; DOI: https://doi.org/10.1124/dmd.8.3.143
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    Effect of phenobarbital treatment and cytochrome P-450 inhibitors on the laurate omega- and (omega - 1)-hydroxylase activities of rat liver microsomes.
    R T Okita and B S Masters
    Drug Metabolism and Disposition May 1980, 8 (3) 147-151; DOI: https://doi.org/10.1124/dmd.8.3.147
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    Facile and definitive determination of human adriamycin and daunoribicin metabolites by high-pressure liquid chromatography.
    P A Andrews, D E Brenner, F T Chou, H Kubo and N R Bachur
    Drug Metabolism and Disposition May 1980, 8 (3) 152-156; DOI: https://doi.org/10.1124/dmd.8.3.152
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    Disposition of 14C-cefatrizine in man.
    R C Gaver and G Deeb
    Drug Metabolism and Disposition May 1980, 8 (3) 157-162; DOI: https://doi.org/10.1124/dmd.8.3.157
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    The metabolic disposition of (S)-2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine in rats, dogs, and humans.
    S Vickers, C A Duncan, B H Arison, R O Davies, R Ferguson and A G Zacchei
    Drug Metabolism and Disposition May 1980, 8 (3) 163-167; DOI: https://doi.org/10.1124/dmd.8.3.163
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    Pharmacokinetics of N-(4-hydroxyphenyl)-all-trans-retinamide in rats.
    B N Swanson, D W Zaharevitz and M B Sporn
    Drug Metabolism and Disposition May 1980, 8 (3) 168-172; DOI: https://doi.org/10.1124/dmd.8.3.168
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    Identification of mephenytoin metabolites in the dog.
    G Karlaganis, A Küpfer, J Bircher, U P Schlunegger, H Gfeller and P Bigler
    Drug Metabolism and Disposition May 1980, 8 (3) 173-177; DOI: https://doi.org/10.1124/dmd.8.3.173
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    Identification of in vivo liver metabolites of delta 6-tetrahydrocannabinol produced by the mouse.
    D J Harvey and W D Paton
    Drug Metabolism and Disposition May 1980, 8 (3) 178-186; DOI: https://doi.org/10.1124/dmd.8.3.178
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    Glucuronyltransferase heterogeneity.
    Drug Metabolism and Disposition May 1980, 8 (3) 187; DOI: https://doi.org/10.1124/dmd.8.3.187
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    Pharmacogenetic studies.
    Drug Metabolism and Disposition May 1980, 8 (3) 187-188; DOI: https://doi.org/10.1124/dmd.8.3.187-a
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    Reactive intermediates from phenacetin.
    Drug Metabolism and Disposition May 1980, 8 (3) 188; DOI: https://doi.org/10.1124/dmd.8.3.188
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    Salicylazosulfapyridine metabolites in milk.
    Drug Metabolism and Disposition May 1980, 8 (3) 188-189; DOI: https://doi.org/10.1124/dmd.8.3.188-a
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    Ethylenethiourea: comparative metabolism.
    Drug Metabolism and Disposition May 1980, 8 (3) 189; DOI: https://doi.org/10.1124/dmd.8.3.189
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In this issue

Drug Metabolism and Disposition
Vol. 8, Issue 3
1 May 1980
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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