Abstract
Metabolites of delta 6-tetrahydrocannabinol (THC) were extracted from livers, separated from lipids by chromatography on Sephadex LH-20, and identified by combined gas chromatography and mass spectrometry. Three alcohols, delta 6-THD-7-oic acid, five diols, six triols, five monohydroxy acids, six dihydroxy acids, two substituted ketones, an epoxide, three diols produced by hydrolysis of the epoxide, three dihydro metabolites, and a glucuronide conjugate were identified. Several other metabolites were detected but not identified. The metabolites were similar to those produced by delta 1-THC in that allylic and side-chain hydroxylation coupled with carboxylic acid formation at C7 were the major biotransformation pathways. delta 6-THC was found to be metabolized more extensively via the epoxide-diol pathway than the delta 1-isomer.
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
