More articles from 50th Anniversary Celebration Collection Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development—Minireview

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Emerging Roles of Uremic Toxins and Inflammatory Cytokines in the Alteration of Hepatic Drug Disposition in Patients with Kidney Dysfunction
Hiroshi Arakawa and Yukio Kato

Drug Metabolism and Disposition September 2023, 51 (9) 1127-1135; DOI: https://doi.org/10.1124/dmd.122.000967
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A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept
Yuichi Sugiyama and Yasunori Aoki

Drug Metabolism and Disposition September 2023, 51 (9) 1067-1076; DOI: https://doi.org/10.1124/dmd.123.001344
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Progress in the Quantitative Assessment of Transporter-Mediated Drug–Drug Interactions Using Endogenous Substrates in Clinical Studies
Tatsuki Mochizuki and Hiroyuki Kusuhara

Drug Metabolism and Disposition September 2023, 51 (9) 1105-1113; DOI: https://doi.org/10.1124/dmd.123.001285
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Preincubation Time-Dependent, Long-Lasting Inhibition of Drug Transporters and Impact on the Prediction of Drug−Drug Interactions
Yoshitane Nozaki and Saki Izumi

Drug Metabolism and Disposition September 2023, 51 (9) 1077-1088; DOI: https://doi.org/10.1124/dmd.122.000970
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Quantitative Consideration of Clinical Increases in Serum Creatinine Caused by Renal Transporter Inhibition
Tomohisa Nakada, Toshiyuki Kudo and Kiyomi Ito

Drug Metabolism and Disposition September 2023, 51 (9) 1114-1126; DOI: https://doi.org/10.1124/dmd.122.000969
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Quantitative Prediction of Intestinal Absorption of Drugs from In Vitro Study: Utilization of Differentiated Intestinal Epithelial Cells Derived from Intestinal Stem Cells at Crypts
Kazuya Maeda

Drug Metabolism and Disposition September 2023, 51 (9) 1136-1144; DOI: https://doi.org/10.1124/dmd.122.000966

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