More articles from Article

You have access
Antibiotics-Induced Disruption of Gut Microbiota Increases Systemic Exposure of Clopidogrel Active Metabolite in Type 2 Diabetic Rats
Xue Chen, Yingrui Liu, Hongwei Yao, Wenfang Song, Yu Song, Jingkai Gu and Yingjie Guo

Drug Metabolism and Disposition September 2022, 50 (9) 1142-1150; DOI: https://doi.org/10.1124/dmd.122.000906
You have access
High-Throughput Production of Diverse Xenobiotic Metabolites with Cytochrome P450–Transduced Huh7 Hepatoma Cell Lines
Choon-myung Lee, Ken H. Liu, Grant Singer, Gary W. Miller, Shuzhao Li, Dean P. Jones and Edward T. Morgan

Drug Metabolism and Disposition September 2022, 50 (9) 1182-1189; DOI: https://doi.org/10.1124/dmd.122.000900
You have access
The rs35217482 (T755I) Single-Nucleotide Polymorphism in Aldehyde Oxidase-1 Attenuates Protein Dimer Formation and Reduces the Rates of Phthalazine Metabolism
Hinata Ueda, Katsuya Narumi, Ayako Furugen, Yoshitaka Saito and Masaki Kobayashi

Drug Metabolism and Disposition September 2022, 50 (9) 1126-1131; DOI: https://doi.org/10.1124/dmd.122.000902
Open Access
The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty

Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829
You have access
Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen

Drug Metabolism and Disposition August 2022, 50 (8) 1077-1086; DOI: https://doi.org/10.1124/dmd.122.000875
You have access
Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack and Tatiana Koudriakova

Drug Metabolism and Disposition August 2022, 50 (8) 1064-1076; DOI: https://doi.org/10.1124/dmd.121.000825
You have access
Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli

Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784
You have access
In Vitro CYP450 Enzyme Downregulation by GLP-1/Glucagon Coagonist Does Not Translate to Observed Drug-Drug Interactions in the Clinic
Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen

Drug Metabolism and Disposition August 2022, 50 (8) 1087-1097; DOI: https://doi.org/10.1124/dmd.122.000865
You have access
HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling
Thomas J. DiProspero, Lauren G. Brown, Trevor D. Fachko and Matthew R. Lockett

Drug Metabolism and Disposition August 2022, 50 (8) 1098-1105; DOI: https://doi.org/10.1124/dmd.122.000870
You have access
Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen

Drug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882

Main menu

User menu

Search

More articles from Article

Pages

Navigate

More Information

ASPET's Other Journals