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Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart

Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676
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Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio
Farzaneh Salem, Khaled Abduljalil, Yoshiteru Kamiyama and Amin Rostami-Hodjegan

Drug Metabolism and Disposition July 2016, 44 (7) 1099-1102; DOI: https://doi.org/10.1124/dmd.115.067595
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Predicting Stereoselective Disposition of Carvedilol in Adult and Pediatric Chronic Heart Failure Patients by Incorporating Pathophysiological Changes in Organ Blood Flows–A Physiologically Based Pharmacokinetic Approach
Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer

Drug Metabolism and Disposition July 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858
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Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
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Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593
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Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
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Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809
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Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk

Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546
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The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)
Luc R.A. Rougée, Zoe Riches, Jacob M. Berman and Abby C. Collier

Drug Metabolism and Disposition July 2016, 44 (7) 967-974; DOI: https://doi.org/10.1124/dmd.115.068650
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Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
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Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
Ronald N. Hines, Pippa M. Simpson and D. Gail McCarver

Drug Metabolism and Disposition July 2016, 44 (7) 959-966; DOI: https://doi.org/10.1124/dmd.115.068957
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Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
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Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518

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