Abstract
Oxprenolol, 1-(o-allyloxyphenoxy)-3-isopropylamino-2-propanol. is a β-receptor blocking agent. In this communication, we report a previously unrecognized metabolic pathway for oxyprenolol in dogs, N-methylation. Tritium-labeled oxprenolol, 5 mg/kg, was administered to beagle dogs. Urine samples were incubated with β-glucuronidase, alkalinized, and extracted with benzene. Using gas chromatograph/mass spectrometer techniques. 1-(o-allyloxyphenoxy)-3-methylamino-2-propanol was identified after administration of oxprenolol. This compound also was identified after administration of 0.5 mg/kg of 1-(o-allyloxyphenoxy)-3-amino-2-propanol. Thus, it appears that oxprenolol in the dog is N-dealkylated and an N-methylation then occurs.
Footnotes
- Received November 20, 1972.
- Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics
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