Abstract
A patient ingested about 250 ml of Cuprex, an ectoparasiticide containing tetralin (1,2,3, 4-tetrahydronaphthalene). copper oleate, paraffin oil, and acetone, in an episode of self-poisoning. This caused a mild degree of liver and kidney damage that subsided within two weeks. The main urinary metabolite of tetralin was 1,2,3,4-tetrahydro-1-naphthol. The glucuronides of this naphthol and of 1,2,3,4-tetrahydro-2-naphthol were also detected in the urine. Hydroxylation of tetralin only on the alicyclic ring and mainly at the benzylic carbon suggests that tetralin metabolism may occur via a pathway involving the formation of free radicals.
Footnotes
- Received November 6, 1972.
- Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics
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