Abstract
O2,2'-Cyclocytidine, an analog of l-β-D-arabinofuranosylcytosine, is a schedule-independent antitumor agent in experimental systems. Its mode of action was studied in L1210 leukemic cells in vivo and in vitro. The phosphorylated products in L1210 leukemic cells of mice that had received cyclo-C1 intravenously were ara-C nucleotides. Since cyclo-C was not directly phosphorylated in vitro, it must have been converted to ara-C before its phosphorylation. Cyclo-C is not deaminated by the abundant deaminase in human livers and mouse kidneys. These results support the probable usefulness of cyclo-C clinically as a depot form of ara-C.
Footnotes
- Received May 31, 1973.
- Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics
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