Abstract
The metabolism of tulobuterol, a new bronchodilating agent, has been studied in the dog, rat, rabbit, and guinea pig. Major basic metabolites of tulobuterol excreted in the urine were identified by comparison of the retention times of a gas chromatogram and/or a mass chromatogram, and of mass spectra with those of the authentic compounds. 4,5-Dihydroxytulobuterol and/or 4-hydroxy-3-methoxytulobuterol were identified in the urine of these species. There were species differences in the extent and direction of ring-hydroxylation and subsequent O-methylation.
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.