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Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Friden, Fredrik Bergstrom, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg
Drug Metabolism and Disposition December 13, 2010, dmd.110.035998; DOI: https://doi.org/10.1124/dmd.110.035998

Article Information

dmd.110.035998
DOI 
https://doi.org/10.1124/dmd.110.035998
PubMed 
21149540
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 20, 2010
  • Accepted December 13, 2010
  • Published online December 13, 2010.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Markus Friden1,3,
  2. Fredrik Bergstrom2,
  3. Hong Wan2,
  4. Mikael Rehngren2,
  5. Gustav Ahlin1,
  6. Margareta Hammarlund-Udenaes1 and
  7. Ulf Bredberg2
  1. 1 Uppsala University;
  2. 2 AstraZeneca R&D Molndal
  1. 3 E-mail: markus.friden{at}farmbio.uu.se

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Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Friden, Fredrik Bergstrom, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg
Drug Metabolism and Disposition December 13, 2010, dmd.110.035998; DOI: https://doi.org/10.1124/dmd.110.035998
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