Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Friden; Fredrik Bergstrom; Hong Wan; Mikael Rehngren; Gustav Ahlin; Margareta Hammarlund-Udenaes; Ulf Bredberg

doi:10.1124/dmd.110.035998

Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Friden, Fredrik Bergstrom, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg

Drug Metabolism and Disposition December 13, 2010, dmd.110.035998; DOI: https://doi.org/10.1124/dmd.110.035998

Markus Friden

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For correspondence: markus.friden@farmbio.uu.se

Fredrik Bergstrom

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Hong Wan

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Mikael Rehngren

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Gustav Ahlin

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Margareta Hammarlund-Udenaes

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Ulf Bredberg

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Drug Metabolism and Disposition

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1 Oct 2023

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Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Friden, Fredrik Bergstrom, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg

Drug Metabolism and Disposition December 13, 2010, dmd.110.035998; DOI: https://doi.org/10.1124/dmd.110.035998

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Research ArticleArticle

Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Friden, Fredrik Bergstrom, Hong Wan, Mikael Rehngren, Gustav Ahlin, Margareta Hammarlund-Udenaes and Ulf Bredberg

Drug Metabolism and Disposition December 13, 2010, dmd.110.035998; DOI: https://doi.org/10.1124/dmd.110.035998

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Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

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