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Research ArticleArticle

Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity

Stephen Castellino, Michael J O'Mara, Kevin M Koch, David Borts, Gary D Bowers and Christopher MacLauchlin
Drug Metabolism and Disposition September 30, 2011, dmd.111.040949; DOI: https://doi.org/10.1124/dmd.111.040949

Article Information

dmd.111.040949
DOI 
https://doi.org/10.1124/dmd.111.040949
PubMed 
21965624
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 2, 2011
  • Accepted September 30, 2011
  • Published online September 30, 2011.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephen Castellino1,3,
  2. Michael J O'Mara1,
  3. Kevin M Koch1,
  4. David Borts2,
  5. Gary D Bowers1 and
  6. Christopher MacLauchlin1
  1. 1 GlaxoSmithKline;
  2. 2 BASF Plan Science
  1. ↵3 E-mail: steve.x.castellino{at}gsk.com

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Research ArticleArticle

Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity

Stephen Castellino, Michael J O'Mara, Kevin M Koch, David Borts, Gary D Bowers and Christopher MacLauchlin
Drug Metabolism and Disposition September 30, 2011, dmd.111.040949; DOI: https://doi.org/10.1124/dmd.111.040949
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