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Prediction of Crizotinib-Midazolam Interaction Using the Simcyp Population-Based Simulator: Comparison of CYP3A Time-Dependent Inhibition Between Human Liver Microsomes Versus Hepatocytes

Jialin Mao, Theodore R Johnson, Zhongzhou Shen and Shinji Yamazaki
Drug Metabolism and Disposition November 5, 2012, dmd.112.049114; DOI: https://doi.org/10.1124/dmd.112.049114

Article Information

dmd.112.049114
DOI 
https://doi.org/10.1124/dmd.112.049114
PubMed 
23129213
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 19, 2012
  • Accepted November 5, 2012
  • Published online November 5, 2012.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jialin Mao,
  2. Theodore R Johnson,
  3. Zhongzhou Shen, and
  4. Shinji Yamazaki1
  1. Pfizer
  1. ↵1 E-mail: shinji.yamazaki{at}pfizer.com

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Research ArticleArticle

Prediction of Crizotinib-Midazolam Interaction Using the Simcyp Population-Based Simulator: Comparison of CYP3A Time-Dependent Inhibition Between Human Liver Microsomes Versus Hepatocytes

Jialin Mao, Theodore R Johnson, Zhongzhou Shen and Shinji Yamazaki
Drug Metabolism and Disposition November 5, 2012, dmd.112.049114; DOI: https://doi.org/10.1124/dmd.112.049114
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