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Research ArticleArticle

High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes are Two Important Predictors of Drug-induced Liver Injury

Ke Yu, Xingchao Geng, Minjun Chen, Jie Zhang, Bingshun Wang, Katarina ilic and Weida Tong
Drug Metabolism and Disposition January 24, 2014, dmd.113.056267; DOI: https://doi.org/10.1124/dmd.113.056267

Article Information

dmd.113.056267
DOI 
https://doi.org/10.1124/dmd.113.056267
PubMed 
24464804
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online January 24, 2014.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ke Yu1,
  2. Xingchao Geng2,
  3. Minjun Chen1,
  4. Jie Zhang1,
  5. Bingshun Wang3,
  6. Katarina ilic4, and
  7. Weida Tong1,5
  1. 1 National Center for Toxicological Research, US Food and Drug Administration;
  2. 2 National Institute for the Control of Pharmaceutical and Biological Products, China's State Food and;
  3. 3 Shanghai Jiao Tong University School of Medicine;
  4. 4 University of Belgrade
  1. ↵5 E-mail: weida.tong{at}fda.hhs.gov

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Research ArticleArticle

High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes are Two Important Predictors of Drug-induced Liver Injury

Ke Yu, Xingchao Geng, Minjun Chen, Jie Zhang, Bingshun Wang, Katarina ilic and Weida Tong
Drug Metabolism and Disposition January 24, 2014, dmd.113.056267; DOI: https://doi.org/10.1124/dmd.113.056267
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