High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes are Two Important Predictors of Drug-induced Liver Injury

Ke Yu; Xingchao Geng; Minjun Chen; Jie Zhang; Bingshun Wang; Katarina ilic; Weida Tong

doi:10.1124/dmd.113.056267

Research ArticleArticle

High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes are Two Important Predictors of Drug-induced Liver Injury

Ke Yu, Xingchao Geng, Minjun Chen, Jie Zhang, Bingshun Wang, Katarina ilic and Weida Tong

Drug Metabolism and Disposition January 24, 2014, dmd.113.056267; DOI: https://doi.org/10.1124/dmd.113.056267

Ke Yu

1 National Center for Toxicological Research, US Food and Drug Administration;

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Xingchao Geng

2 National Institute for the Control of Pharmaceutical and Biological Products, China's State Food and;

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Minjun Chen

1 National Center for Toxicological Research, US Food and Drug Administration;

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Jie Zhang

1 National Center for Toxicological Research, US Food and Drug Administration;

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Bingshun Wang

3 Shanghai Jiao Tong University School of Medicine;

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Katarina ilic

4 University of Belgrade

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Weida Tong

1 National Center for Toxicological Research, US Food and Drug Administration;

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For correspondence: weida.tong@fda.hhs.gov

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Drugs-substrates, inhibitors, and inducers of CYP enzymes with the daily dose and lipophilicity

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Drug Metabolism and Disposition

Vol. 51, Issue 10

1 Oct 2023

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Research ArticleArticle

High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes are Two Important Predictors of Drug-induced Liver Injury

Ke Yu, Xingchao Geng, Minjun Chen, Jie Zhang, Bingshun Wang, Katarina ilic and Weida Tong

Drug Metabolism and Disposition January 24, 2014, dmd.113.056267; DOI: https://doi.org/10.1124/dmd.113.056267

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Research ArticleArticle

High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes are Two Important Predictors of Drug-induced Liver Injury

Ke Yu, Xingchao Geng, Minjun Chen, Jie Zhang, Bingshun Wang, Katarina ilic and Weida Tong

Drug Metabolism and Disposition January 24, 2014, dmd.113.056267; DOI: https://doi.org/10.1124/dmd.113.056267

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High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes are Two Important Predictors of Drug-induced Liver Injury

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