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Drug Metabolism & Disposition

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Research ArticleArticle

6β-hydroxycortisol is an Endogenous Probe for Evaluation of Drug-drug Interaction Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects

Yuichiro Imamura, Yuri Tsuruya, Katja Damme, Dominik Heer, Yuji Kumagai, Kazuya Maeda, Nobuyuki Murayama, Noriko Okudaira, Atsushi Kurihara, Takashi Izumi, Yuichi Sugiyama and Hiroyuki Kusuhara
Drug Metabolism and Disposition January 31, 2014, dmd.113.055475; DOI: https://doi.org/10.1124/dmd.113.055475
Yuichiro Imamura
1 Daiichi Sankyo Co.;
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Yuri Tsuruya
2 Graduate School of Pharmaceutical Sciences, the University of Tokyo;
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Katja Damme
3 Daiichi Sankyo Europe GmbH;
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Dominik Heer
3 Daiichi Sankyo Europe GmbH;
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Yuji Kumagai
4 Kitasato East Hospital;
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Kazuya Maeda
5 Graduate School of Pharmaceutical Sciences, Univ. of Tokyo;
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Nobuyuki Murayama
1 Daiichi Sankyo Co.;
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Noriko Okudaira
1 Daiichi Sankyo Co.;
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Atsushi Kurihara
1 Daiichi Sankyo Co.;
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Takashi Izumi
1 Daiichi Sankyo Co.;
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Yuichi Sugiyama
6 RIKEN;
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Hiroyuki Kusuhara
7 The University of Tokyo
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  • For correspondence: kusuhara@mol.f.u-tokyo.ac.jp
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      Supplemental Table 1 - Outlines of clinical studies the plasma and urine samples from which were used in this study

      Supplemental Table 2 - The uptake of reference compounds in human kidney slices, and the effect of typical inhibitors

      Supplemental Table 3 - Comparison of apparent formation clearance of 6beta-OHF (CL6beta-OHF)

      Supplemental Figure 1 - Effect of probenecid and pyrimethamine on the plasma concentrations of cortisol in healthy subjects

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Drug Metabolism and Disposition: 50 (5)
Drug Metabolism and Disposition
Vol. 50, Issue 5
1 May 2022
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Research ArticleArticle

6β-hydroxycortisol is an Endogenous Probe for Evaluation of Drug-drug Interaction Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects

Yuichiro Imamura, Yuri Tsuruya, Katja Damme, Dominik Heer, Yuji Kumagai, Kazuya Maeda, Nobuyuki Murayama, Noriko Okudaira, Atsushi Kurihara, Takashi Izumi, Yuichi Sugiyama and Hiroyuki Kusuhara
Drug Metabolism and Disposition January 31, 2014, dmd.113.055475; DOI: https://doi.org/10.1124/dmd.113.055475

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Research ArticleArticle

6β-hydroxycortisol is an Endogenous Probe for Evaluation of Drug-drug Interaction Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects

Yuichiro Imamura, Yuri Tsuruya, Katja Damme, Dominik Heer, Yuji Kumagai, Kazuya Maeda, Nobuyuki Murayama, Noriko Okudaira, Atsushi Kurihara, Takashi Izumi, Yuichi Sugiyama and Hiroyuki Kusuhara
Drug Metabolism and Disposition January 31, 2014, dmd.113.055475; DOI: https://doi.org/10.1124/dmd.113.055475
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