Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Figure 1 - Structures of compounds used in the current study
Supplemental Figure 2 - Comparison of scaled CLint,animal relative to CLint,human values obtained in hepatocytes
Supplemental Table 1 - Tissue-specific expression profile of CES1 and CES2 isozymes in mammals and humans
Supplemental Table 2 - Half-life (t1/2) values obtained in plasma of human, monkey, dog and rat
Supplemental Table 3 - CLint values in kidney S9 of human, monkey, dog and rat scaled by two kinds of scaling factors
Supplemental Table 4 - Blood to plasma ratios, plasma protein binding and observed and predicted hepatic intrinsic clearances for 8 CES1 substrates
References for clinical data
- Supplemental Data -