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Research ArticlePerspective

Contribution of Metabolites to P450 Inhibition-Based Drug-Drug Interactions: Scholarship from the IQ DMLG Metabolite Group

Hongbin Yu, Suresh K. Balani, Weichao Chen, Donghui Cui, Ling He, William Griffith Humphreys, Jialin Mao, W. George Lai, Anthony J. Lee, Heng-Keang Lim, Christopher MacLauchlin, Chandra Prakash, Sekhar Surapaneni, Susanna Tse, Alana Upthagrove, Robert L. Walsky, Bo Wen and Zhaopie Zeng
Drug Metabolism and Disposition February 5, 2015, dmd.114.059345; DOI: https://doi.org/10.1124/dmd.114.059345
Hongbin Yu
1 Boehringer Ingelheim Pharmaceuticals. Inc.;
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  • For correspondence: hongbin.yu@boehringer-ingelheim.com
Suresh K. Balani
2 Takeda Pharmaceuticals International Co.;
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Weichao Chen
3 Vertex Pharmaceuticals;
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Donghui Cui
4 Merck Research Laboratories;
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Ling He
5 Daiichi Sankyo, Inc.;
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William Griffith Humphreys
6 Bristol-Myers-Squibb;
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Jialin Mao
7 Genentech;
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W. George Lai
8 Eisai Pharmaceuticals;
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Anthony J. Lee
9 Abbivie;
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Heng-Keang Lim
10 Janssen Research and Development;
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Christopher MacLauchlin
11 GlaxoSmithKline;
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Chandra Prakash
12 Biogen Idec;
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Sekhar Surapaneni
13 Celgene Corporation;
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Susanna Tse
14 Pfizer Inc.;
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Alana Upthagrove
15 Novartis Pharmaceuticals Corporation;
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Robert L. Walsky
16 EMD Serono Research Institute;
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Bo Wen
11 GlaxoSmithKline;
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Zhaopie Zeng
17 Sanofi
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Article Information

dmd.114.059345
DOI 
https://doi.org/10.1124/dmd.114.059345
PubMed 
25655830

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online February 5, 2015.

Article Versions

  • You are currently viewing an Earlier version of this article (February 5, 2015 - 07:23).
  • View the most recent version of this article
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hongbin Yu1,18,
  2. Suresh K. Balani2,
  3. Weichao Chen3,
  4. Donghui Cui4,
  5. Ling He5,
  6. William Griffith Humphreys6,
  7. Jialin Mao7,
  8. W. George Lai8,
  9. Anthony J. Lee9,
  10. Heng-Keang Lim10,
  11. Christopher MacLauchlin11,
  12. Chandra Prakash12,
  13. Sekhar Surapaneni13,
  14. Susanna Tse14,
  15. Alana Upthagrove15,
  16. Robert L. Walsky16,
  17. Bo Wen11, and
  18. Zhaopie Zeng17
  1. 1 Boehringer Ingelheim Pharmaceuticals. Inc.;
  2. 2 Takeda Pharmaceuticals International Co.;
  3. 3 Vertex Pharmaceuticals;
  4. 4 Merck Research Laboratories;
  5. 5 Daiichi Sankyo, Inc.;
  6. 6 Bristol-Myers-Squibb;
  7. 7 Genentech;
  8. 8 Eisai Pharmaceuticals;
  9. 9 Abbivie;
  10. 10 Janssen Research and Development;
  11. 11 GlaxoSmithKline;
  12. 12 Biogen Idec;
  13. 13 Celgene Corporation;
  14. 14 Pfizer Inc.;
  15. 15 Novartis Pharmaceuticals Corporation;
  16. 16 EMD Serono Research Institute;
  17. 17 Sanofi
  1. ↵18 E-mail: hongbin.yu{at}boehringer-ingelheim.com

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Drug Metabolism and Disposition: 49 (3)
Drug Metabolism and Disposition
Vol. 49, Issue 3
1 Mar 2021
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Research ArticlePerspective

Contribution of Metabolites to P450 Inhibition-Based Drug-Drug Interactions: Scholarship from the IQ DMLG Metabolite Group

Hongbin Yu, Suresh K. Balani, Weichao Chen, Donghui Cui, Ling He, William Griffith Humphreys, Jialin Mao, W. George Lai, Anthony J. Lee, Heng-Keang Lim, Christopher MacLauchlin, Chandra Prakash, Sekhar Surapaneni, Susanna Tse, Alana Upthagrove, Robert L. Walsky, Bo Wen and Zhaopie Zeng
Drug Metabolism and Disposition February 5, 2015, dmd.114.059345; DOI: https://doi.org/10.1124/dmd.114.059345

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Research ArticlePerspective

Contribution of Metabolites to P450 Inhibition-Based Drug-Drug Interactions: Scholarship from the IQ DMLG Metabolite Group

Hongbin Yu, Suresh K. Balani, Weichao Chen, Donghui Cui, Ling He, William Griffith Humphreys, Jialin Mao, W. George Lai, Anthony J. Lee, Heng-Keang Lim, Christopher MacLauchlin, Chandra Prakash, Sekhar Surapaneni, Susanna Tse, Alana Upthagrove, Robert L. Walsky, Bo Wen and Zhaopie Zeng
Drug Metabolism and Disposition February 5, 2015, dmd.114.059345; DOI: https://doi.org/10.1124/dmd.114.059345
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