Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Table 1 - Primers used for PCR amplification and sequencing of CYP2C19 exons from genomic DNA

  Supplemental Table 2 - Optimized MS/MS parameters of CYP2C19 surrogate peptides used for protein quantification

  Supplemental Table 3 - CYP2C19*2/*35 diplotypes and CYP2C19*2 and CYP2C19*35 allele frequencies in different populations (1000 genome-Phase 3 data)

  Supplemental Table 4 - Full length sequencing of the CYP2C19*35 cDNA

  Supplemental Figure 1 - Visual genotypes of rs12769205 and rs4244285 in populations of African descent (1000 genomes phase 3 data)

  Supplemental Figure 2 - Linkage disequilibrium (LD) map for the common CYP2C19 allelic variants in the YRI population

  Supplemental Figure 3 - CYP2C19 haplotype frequencies, extended haplotype homozygosity, and ancestral tree in other African populations in the 1000 genome project