Data Supplement

Files in this Data Supplement:

• Supplemental Tables -

  Supplemental Table 1 - Binding of dapagliflozin to protein sources (HEK cell lysate and HLM) in the absence and presence of BSA (1% w/v)

  Supplemental Table 2 - Binding of canagliflozin to protein sources (HEK cell lysate and HLM) in the absence and presence of BSA (0.5% w/v)

  Supplemental Table 3 - Binding of 4-methylumbelliferone to HEK cell lysate in the presence of BSA (0.5 and 1% w/v)

  Supplemental Table 4 - Binding of propofol to protein sources (HEK cell lysate and HLM) in the presence of BSA (0.5 and 1% w/v)

  Supplemental Table 5 - Binding of beta-estradiol to HEK cell lysate and HLM

  Supplemental Table 6 - HPLC conditions for the quantification of canagliflozin, dapagliflozin, beta-estradiol, 4-methylumbelliferone and propofol in dialysates from equilibrium dialysis experiments