Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Materials and Methods

  Supplemental Table 1 - Detection of herbal compounds in ReDuNing injection

  Supplemental Table 2A - Detection of metabolites of geniposide (6), chlorogenic acid (30), cryptochlorogenic acid (31), and neochlorogenic acid (29) in rats intravenously receiving ReDuNing injection

  Supplemental Figure 1 - Systemic exposure to and excretion of metabolites of geniposide (6), secologanic acid (4), chlorogenic acid (30), cryptochlorogenic acid (31), and neochlorogenic acid (29) in rats receiving a 30-minute intravenous infusion of ReDuNing injection (lot number, 141106) at 2 ml/kg

  Supplemental Figure 2 - Plasma concentrations of major circulating iridoids and organic acids over time in rats receiving a 30-minute intravenous infusion of ReDuNing injection at 2 ml/kg