Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Figure 1 - Product Ion Mass Spectra of Venetoclax and Its Metabolites
Supplemental Figure 2 - 1H NMR Spectra of Venetoclax, M2, and M18 in Aromatic Region (A) and in Aliphatic Region (B)
Supplemental Figure 3 - Chiral Confirmation of M27
Supplemental Figure 4 - Product Ion Mass Spectra of the Degradation Peak and Proposed Fragmentation Pathways
Supplemental Figure 5 - Proposed Formation Mechanism of the Degradation Peak from M27
Supplemental Table 1 - Molecular Ions and Characteristic Fragment Ions of Metabolites that were Detected by LC/MS only
Supplemental Table 2 - Estimated Relative Amounts (%AUC0-24) of M27 at Steady State in Mouse, Dog and Human Plasma Samples following Oral Doses of Venetoclax
- Supplemental Data -