Data Supplemental

• Supplemental Data -

  Supplemental Methods

  Supplemental Figure 1 - Elution profiles of UGT Q-peptides analyzed in the same LC-MS/MS assay (sample HH06)
  

  Supplemental Figure 2 - Correlation of UGT abundance values measured using the two QconCAT peptides representing UGT1A1 (A), UGT1A4 (B), UGT1A6 (C), UGT2B4 (D), UGT2B7 (E) and UGT2B15 (F) after optimization
  

  Supplemental Figure 3 - Cross-laboratory evaluation of UGT abundance measurements using stable isotope-labeled
  (SIL) peptide standards and quantification concatemer (QconCAT) standard: Box and whiskers plot of the abundance
  measurements (n=24) of UGT enzymes quantified by the two methods (A) with the individual values shown in panel
  (B)
  

  Supplemental Figure 4 - Correlation between individual protein abundance measurements (n=24) of UGTs 1A1 (A), 1A3 (B), 1A4 (C), 1A6 (D), 1A9 (E), 2B4 (F), 2B7 (G) and 2B15 (H) using two proteomic methodologies (SIL vs QconCAT) after optimization of QconCAT data analysis
  

  Supplemental Figure 5 - Correlation matrix of individual protein abundances of UGT enzymes (abundance vs abundance) using QconCAT methodology (n=24)
  

  Supplemental Table 1 - Comparison of QconCAT-based UGT measurements before and after optimization of data analysis
  

  Supplemental Table 2 - Correlation matrix of QconCAT-derived individual UGT enzyme abundances (n=24) with activity rates (abundance vs activity)
  

  Supplemental Table 3 - Correlation matrix of individual protein abundances of UGT enzymes (abundance vs abundance) using QconCAT methodology (n=24)
  

  Supplemental Table 4 - Enzymes with established QconCAT-based quantification methods after optimization
  

  References