Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans

Yuki Yamasaki; Kaoru Kobayashi; Fuka Okuya; Naoyo Kajitani; Kanako Kazuki; Satoshi Abe; Shoko Takehara; Shingo Ito; Seiryo Ogata; Tatsuki Uemura; Sumio Ohtsuki; Genki Minegishi; Hidetaka Akita; Kan Chiba; Mitsuo Oshimura; Yasuhiro Kazuki

doi:10.1124/dmd.118.081216

Research ArticleArticle

Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans

Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki

Drug Metabolism and Disposition May 18, 2018, dmd.118.081216; DOI: https://doi.org/10.1124/dmd.118.081216

Yuki Yamasaki

1 Chiba University;

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Kaoru Kobayashi

1 Chiba University;

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For correspondence: kaoruk@faculty.chiba-u.jp kazuki@grape.med.tottori-u.ac.jp

Fuka Okuya

1 Chiba University;

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Naoyo Kajitani

2 Tottori University;

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Kanako Kazuki

2 Tottori University;

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Satoshi Abe

2 Tottori University;

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Shoko Takehara

2 Tottori University;

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Shingo Ito

3 Kumamoto University

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Seiryo Ogata

3 Kumamoto University

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Tatsuki Uemura

3 Kumamoto University

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Sumio Ohtsuki

3 Kumamoto University

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Genki Minegishi

1 Chiba University;

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Hidetaka Akita

1 Chiba University;

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Kan Chiba

1 Chiba University;

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Mitsuo Oshimura

2 Tottori University;

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Yasuhiro Kazuki

2 Tottori University;

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For correspondence: kaoruk@faculty.chiba-u.jp kazuki@grape.med.tottori-u.ac.jp

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Research ArticleArticle

Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans

Drug Metabolism and Disposition May 18, 2018, dmd.118.081216; DOI: https://doi.org/10.1124/dmd.118.081216

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Research ArticleArticle

Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans

Drug Metabolism and Disposition May 18, 2018, dmd.118.081216; DOI: https://doi.org/10.1124/dmd.118.081216

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