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Research ArticleMinireview

CYP-humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis Pankowicz, Qing-Yu Zhang and Xinxin Ding
Drug Metabolism and Disposition August 9, 2018, dmd.118.083303; DOI: https://doi.org/10.1124/dmd.118.083303
Karl-Dimiter Bissig
1 Baylor College of Medicine;
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  • For correspondence: xding@pharmacy.arizona.edu bissig@bcm.edu
Weiguo Han
2 University of Arizona College of Pharmacy
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Mercedes Barzi
1 Baylor College of Medicine;
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Nataliia Kovalchuk
2 University of Arizona College of Pharmacy
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Liang Ding
2 University of Arizona College of Pharmacy
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Xiaoyu Fan
2 University of Arizona College of Pharmacy
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Francis Pankowicz
1 Baylor College of Medicine;
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Qing-Yu Zhang
2 University of Arizona College of Pharmacy
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Xinxin Ding
2 University of Arizona College of Pharmacy
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  • For correspondence: xding@pharmacy.arizona.edu bissig@bcm.edu
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Abstract

Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost effective and rapid development of new therapies.

  • animal models
  • cytochrome P450
  • genetically modified animal models
  • liver/hepatic
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 51 (10)
Drug Metabolism and Disposition
Vol. 51, Issue 10
1 Oct 2023
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Research ArticleMinireview

CYP-humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis Pankowicz, Qing-Yu Zhang and Xinxin Ding
Drug Metabolism and Disposition August 9, 2018, dmd.118.083303; DOI: https://doi.org/10.1124/dmd.118.083303

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Research ArticleMinireview

CYP-humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis Pankowicz, Qing-Yu Zhang and Xinxin Ding
Drug Metabolism and Disposition August 9, 2018, dmd.118.083303; DOI: https://doi.org/10.1124/dmd.118.083303
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