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Research ArticleMinireview

How to determine the role of the microbiome in drug disposition

Jordan E Bisanz, Peter Spanogiannopoulos, Lindsey M Pieper, Annamarie E Bustion and Peter J Turnbaugh
Drug Metabolism and Disposition August 15, 2018, dmd.118.083402; DOI: https://doi.org/10.1124/dmd.118.083402
Jordan E Bisanz
University of California, San Francisco
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Peter Spanogiannopoulos
University of California, San Francisco
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Lindsey M Pieper
University of California, San Francisco
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Annamarie E Bustion
University of California, San Francisco
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Peter J Turnbaugh
University of California, San Francisco
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  • For correspondence: peter.turnbaugh@ucsf.edu
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Abstract

With a paradigm shift occurring in health care towards personalized and precision medicine, understanding the numerous environmental factors that impact drug disposition is of paramount importance. The highly diverse and variant nature of the human microbiome is now recognized as a factor driving inter-individual variation in therapeutic outcomes. The purpose of this review is to provide a practical guide on methodology that can be applied to study the effects of microbes on the absorption, distribution, metabolism, and excretion of drugs. We also highlight recent examples of how these methods have been successfully applied to help build the basis for researching the intersection of microbiome and pharmacology. While in vitro and in vivo preclinical models are highlighted, these methods are also relevant in late-phase drug development or even as a part of routine after-market surveillance. These approaches will aid in filling major knowledge gaps for both current and upcoming therapeutics with the long-term goal of achieving a new type of knowledge-based medicine that integrates data on the host and the microbiome.

  • animal models
  • bile acid metabolism/transport
  • biliary excretion
  • drug efficacy
  • drug toxicity
  • efflux transporters (P-gp, BCRP, MRP, MATE, BSEP, etc)
  • microbiome
  • pharmacogenetics/pharmacogenomics
  • systems biology
  • transcriptomics
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 49 (5)
Drug Metabolism and Disposition
Vol. 49, Issue 5
1 May 2021
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Research ArticleMinireview

How to determine the role of the microbiome in drug disposition

Jordan E Bisanz, Peter Spanogiannopoulos, Lindsey M Pieper, Annamarie E Bustion and Peter J Turnbaugh
Drug Metabolism and Disposition August 15, 2018, dmd.118.083402; DOI: https://doi.org/10.1124/dmd.118.083402

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Research ArticleMinireview

How to determine the role of the microbiome in drug disposition

Jordan E Bisanz, Peter Spanogiannopoulos, Lindsey M Pieper, Annamarie E Bustion and Peter J Turnbaugh
Drug Metabolism and Disposition August 15, 2018, dmd.118.083402; DOI: https://doi.org/10.1124/dmd.118.083402
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