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Research ArticleArticle

When does the rate-determining step in the hepatic clearance of a drug switch from sinusoidal uptake to all hepatobiliary clearances? Implications for predicting drug-drug interactions

Gabriela I Patilea-Vrana and Jashvant Unadkat
Drug Metabolism and Disposition August 16, 2018, dmd.118.081307; DOI: https://doi.org/10.1124/dmd.118.081307

Article Information

dmd.118.081307
DOI 
https://doi.org/10.1124/dmd.118.081307
PubMed 
30115647
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online August 16, 2018.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gabriela I Patilea-Vrana and
  2. Jashvant Unadkat1
  1. University of Washington
  1. ↵*Address correspondence to: jash{at}uw.edu

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Research ArticleArticle

When does the rate-determining step in the hepatic clearance of a drug switch from sinusoidal uptake to all hepatobiliary clearances? Implications for predicting drug-drug interactions

Gabriela I Patilea-Vrana and Jashvant Unadkat
Drug Metabolism and Disposition August 16, 2018, dmd.118.081307; DOI: https://doi.org/10.1124/dmd.118.081307
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